Rat Liver DT-Diaphorase as a Nitroso-Reductase
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概要
- 論文の詳細を見る
Reduction of several nitroso-compounds by purified DT-diaphorase from rat liver cytosol was investigated. Among nitroso-compounds tested, 1-nitroso-2-naphthol and p-nitrosophenol were reduced in the presence of reduced nicotinamide adenine dinucleotide phosphate (NADPH) at rates much faster than that of nitrosobenzene. On the contrary, none of the N-nitroso-compounds tested was reduced by this enzyme. Experiments on the identification of reduction products and on the inhibition with dicoumarol and the antiserum indicated that DT-diaphorase catalyzes 4-electron reduction of C-nitroso-compounds and plays a major role in the reduction of these compounds by rat liver cytosol.
- 社団法人日本薬学会の論文
- 1990-04-25
著者
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吉村 英敏
中村学園大・食物栄養
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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古賀 信幸
Faculty of Pharmaceutical Sciences, Kyushu University
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外間-黒木 由美子
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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外間-黒木 由美子
Faculty Of Pharmaceutical Sciences Kyushu University
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