医薬品の生体内変化に関する研究(第85報)1-p-Chlorophenyl-2,3-dimethyl-4-dimethylaminobutan-2-ol Hydrochlorideの代謝に関する研究
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概要
- 論文の詳細を見る
The metabolic fate of 1-p-chlorophenyl-2,3-dimethyl-4-dimethylaminobutan-2-ol hydrochloride (CDDA・HCl) in rabbits, rats, and human was studied. 1) In rabbits and rats receiving ^3H-CDDA・HCl orally, the radioactivity was mainly recovered in 24 hr urine. The summation of radioactivity excreted in urine and feces during 96 hr was about 89% and 80% in rabbits and rats, respectively. 2) In rabbits, the urinary metabolites detected were 1-p-chlorophenyl-2,3-dimethyl-4-monomethylaminobutan-2-ol (CDMA), 1-p-chlorophenyl-2,3-dimethyl-4-aminobutan-2-ol (CDA), p-chlorobenzoic acid, benzoic acid, and hippuric acid. 3) In rats, similar result was obtained, except the excretion of p-chlorobenzoic acid found in rabbits. In humans orally receiving non-radioactive CDDA・HCl, the urinary excretion of CDMA and CDA was also suggested.
- 社団法人日本薬学会の論文
- 1975-06-25
著者
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辰巳 淳
広島大・医・薬
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北村 繁幸
広島大・医・薬
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中野 正行
九州大学薬学部
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吉村 英敏
中村学園大・食物栄養
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辰巳 淳
九州大学薬学部
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北村 繁幸
九州大学薬学部
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吉村 英敏
九州大学薬学部
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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