医薬品の生体内変化に関する研究(第74報)メタプロテレノールの代謝について2

概要

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The metabolic fate of ^<14>C-Metaproterenol [1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol] was investigated by its oral administration to rabbits, rats, and mice. In all cases the radioactivity was found more in feces than in urine. On the other hand, a negligible amount of radioactivity was found in bile of the rabbit and in expiratory air of the mouse. Examination on the urinary metabolites by ion exchange chromatography denied the glucuronide formation of this drug in rabbits, although it suggested the production of acidic or neutral metabolites. These findings strongly suggested that absorption of this drug from gastrointestinal tract was rather poor and this might be one of the major reasons for much lower activity by oral than parenteral administration.
公益社団法人日本薬学会の論文
1971-06-25