Enzymatic Hydrolysis of Mono-n-alkyl Substituted Ethylene Oxides and Their Inhibitory Effects on Hepatic Microsomal Epoxide Hydrolase

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概要

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• Hydrolysis of oxides of n-1-olefins, heptene, octene, decene, dodecene, tetradecene, and hexadecene, by hepatic microsomal epoxide hydrolase and their inhibitory effects on the hydrolase activity have been described. Enzymatic reaction rates were the highest in heptene oxide, high in tetradecene and hexadecene oxides, and the lowest in decene oxide. The decene oxide inhibited enzymatic hydrolysis of safrole oxide most significantly ; much more significant than octene oxide that is recognized as a potent inhibitor. A curve representing relationship between alkyl side chain length of the n-1-olefin oxides and their enzymatic reaction rates showed a reciprocal pattern to that for their inhibitory effects on the hydrolase activity.

• 1974-09-25

著者

• 渡部 烈

  Biochemical Laboratory Division Of Organic Chemistry Tokyo College Of Pharmacy

• 赤松 和子

  Biochemical Laboratory, Division of Organic Chemistry, Tokyo College of Pharmacy

• 赤松 和子

  Biochemical Laboratory Division Of Organic Chemistry Tokyo College Of Pharmacy

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