Metabolism of Drugs. XVII. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (7). Separation and Identification of Biotransformation Products of Methylhexabital in the Urine of Rabbits by Paper Chromatography.
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概要
- 論文の詳細を見る
Examination of urinary product of rabbits administered with MHB, by filter paper chromatography, indicated that ureide, 3-OH-MHB, 3-keto-MHB, 3-keto-nor-MHB, and unknown compounds (MHB-M (VI)) were excreted. An excellent method for the separation of these compounds is the use of a buffered filter paper and butanol saturated with borate-NaOH buffer (pH 11). For detection of the located metabolites, 1% solution of sodium periodate and 1% solution of potassium permanganate were used and ultraviolet spectrophotometry was adopted for the characterization of barbiturates.
- 公益社団法人日本薬学会の論文
- 1958-02-20
著者
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塚元 久雄
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Pharmaceutical Institute Medical Faculty University Of Kyushu
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土岐 智
Faculty of Pharmaceutical Science, Fukuoka University
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土岐 智
Faculty Of Pharmaceutical Science Fukuoka University
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土岐 智
Pharmaceutical Institute, Medical Faculty, University of Kyushu
関連論文
- Metabolism of Drugs. XXI. Isolation and Detection of Hydroxyl Derivatives from the Urine of Rabbits receiving Ethylhexabital (EHB, 5-Cyclohexenyl-5-ethylbarbituric Acid) and Normethylhexabital (Nor-MHB, 5-Cyclohexenyl-5-methylbarbituric Acid).
- Metabolism of Drugs. XII. The Effect of β-Diethylaminoethyl Diphenylpropylacetate Hydrochloride (SKF 525-A) on the Metabolism of Ethylhexabital.
- Metabolism of Drugs. LI. The Metabolic Fate of Alkylaryl Ethers in Rabbits
- The Occurrence of (ω-1)-Hydroxylation as the Major Metabolism of Alkylaryl Ethers in Rabbits
- Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
- Metabolism of Drugs. LXXIII. The Metabolic Fate of Nitrofuran Derivatives. (1) Studies on the Absorption and Excretion
- Metabolism of Drugs. LXX. Further Study on Antipyrine Metabolism
- Metabolism of Drugs. LXIX. Studies on the Urinary Metabolites of Morphine in Several Mammalian Species
- 医薬品の生体内変化に関する研究(第71報) : アミノピリンの代謝について
- Metabolism of Drugs. LXVII. The Metabolic Fate of Isoprophenamine
- 医薬品の生体内変化に関する研究(第68報) : メタプロテレノールの代謝について1
- 医薬品の生体内変化に関する研究(第66報) : Pantethineの生体内変化について
- On the Structure of Morphine-6-glucuronide in a Solid State
- ライスオイル中毒症(いわゆる油症)特にその原因毒物の化学的究明について
- Metabolism of Drugs. LXIV. Species Differences of Metabolism of Phenacetylurea
- Metabolism of Drugs. LX. The Synthesis of Codeine and Morphine Glucuronides
- 大麻草の裁判化学的研究III. : 大麻成分検出法の実際鑑定への応用(2)
- 大麻草の裁判化学的研究II. : 大麻成分検出法の実際鑑定への応用(1)
- メチルオレンジ法によるモルヒネ定量の変法
- 医薬品の生体内変化に関する研究(第61報) : イソプロフェナミンの家兎およびマウスにおける生体内分布ならびに排泄について
- Forensic Chemical Study on Marihuana. I. A Detection Method of the Principal Constituents by Thin-layer and Gas Chromatographies
- 医薬品の生体内変化に関する研究(第58報) : 4-ブチルアミノアンチピリンの生体内変化について
- 医薬品の生態内変化に関する研究(第55報) : p-ニトロフェニルグルクロナイドの生体内加水分解について
- Metabolism of Drugs. L II.Enzymatic Study on Secobarbital Metabolism
- 医薬品の生体内変化に関する研究(第54報) : カルバメート N-グルクロナイドの薬理作用について
- Metabolism of Drugs. XIV. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (2)
- Isolation of Glucuronide of p-Aminosalicylic Acid
- Effect of Phenobarbital Derivatives on the Duration of Hexobarbital Hypnosis
- Metabolism of Drugs. XXII. The Metabolic Fate of Thiamylal. (1)
- 薬品の生体内変化に関する研究(第5報)Ethylhexabital代謝産物の排泄速度
- Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.
- Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
- Detection of Morphine in Urine. II. An Improved Method by Thin-Layer Chromatography Utilizing Potassium Platinum Iodide as the Reagent for Both Coloration and Fluorescence
- ヨウ化白金酸カリウムによるモルヒネの瑩光反応ならびにその検出法への応用
- Detection of Morphine in Urine
- 医薬品の生体内変化に関する研究(第8報)メチルヘキサビタールの生体内変化 その4 メチルヘキサビタール代謝物及び関連化合物の紫外, 赤外線吸収スペクトルについて
- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Metabolism of Drugs. XIII. The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (5). Further Studies on Isolation, Characterisation, and Identification of Biotransformation Products of the Drug excreted in the Urine of Rabbi
- Metabolism of Drugs. XVI. The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (6). Studies on the Reduction of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and on Pharmacological Activity of the Biotran
- 薬品の生体内変化に関する研究(第1報) : Ethylhexabital(5-Cyclohexenyl-5-ethylbarbituric Acid)の生体内変化
- 医薬品の生体内変化に関する研究(第53報) : カルバメートN-グルクロナイドの生体内変化について
- 薬物代謝と毒性
- Metabolism of Drugs. L. The In Vitro Study on Metabolism of Brucine and 4-Substituted Veratroles
- Metabolism of Drugs. XXIX. Metabolic Fate of Meprobamate. (2). Further Studies on the Structure of the Metabolites.
- Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
- Metabolism of Drugs. XVIII. : The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (8). : The Quantitative Determination of Main Biotransformation Products of Methylhexabital in the Urine of Rabbits by Ultraviolet Spectropho
- Metabolism of Drugs. XVII. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (7). Separation and Identification of Biotransformation Products of Methylhexabital in the Urine of Rabbits by Paper Chromatography.
- 医薬品の生体内変化に関する研究(第7報)メチルヘキサビタールの生体内変化 その3 メチルヘキサビタール代謝物について
- Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
- 薬品の生体内変化に関する研究(第4報)p-Aminosalicylic Acidの家兎における生体内変化 その1
- Hexobarbital Metabolism. Formation of α-1,5-Dimethyl-5-(3-hydroxy-1-cyclohexen-1-yl)-barbituric Acid Glucuronide
- Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
- Enzymatic Oxidation of Methylhexabital
- Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi
- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.
- 医薬品の生体内変化に関する研究(第6報)メチルヘキサビタールの生体内変化 その2 メチルヘキサビタール及びノルメチルヘキサビタールのクロム酸酸化について
- 薬品の生体内変化に関する研究(第2報)Ethylhexabital(5-Cyclo-5-ethylbarbituric Acid)の生体内変化
- 薬品の生体内変化に関する研究(第3報)Methylexabital(5-Cyclohexenyl-3,5-dimethyl-barbituric Acid)の生体内変化 その1