Metabolism of Drugs. XXII. The Metabolic Fate of Thiamylal. (1)
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概要
- 論文の詳細を見る
Thiamylal was orally administered to rabbits and its metabolites excreted in urine were examined, mainly by paper chromatography. One of the metabolites was isolated and characterized as a carboxylic acid with thiobarbituric acid ring and allyl side-chain. Comparing the paper chromatogram of urine of rabbits receiving thiamylal or secobarbital, it was apparent that thiamylal was metabolized to the compounds not only with thiobarbituric acid ring and its oxygen homologs but also without the ring structure.
- 公益社団法人日本薬学会の論文
- 1960-03-25
著者
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塚元 久雄
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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高畠 英伍
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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井出 博之
Facutly Of Pharmaceutical Sciences Kyushu University
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塚元 久雄
Pharmaceutical Institute. Medical Faculty University Of Kyushu
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井出 博之
Pharmaceutical Institute. Medical Faculty, University of Kyushu
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高畠 英伍
Pharmaceutical Institute Medical Faculty University Of Kyushu
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高畠 英伍
Pharmaceutical Institute. Medical Faculty University Of Kyushu
関連論文
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- エチルヘキサビタールの生体内変化に関する研究-3-
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- Ethylhexabitalのラッて肝臓切片による試験管内変化
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
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- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Biochemical Studies on the Drug Metabolism. I. Some Factors Affecting on the Metabolism of Cyclobarbital.
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- 医薬品の生体内変化に関する研究(第7報)メチルヘキサビタールの生体内変化 その3 メチルヘキサビタール代謝物について
- Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
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- Enzymatic Oxidation of Methylhexabital
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- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.
- 医薬品の生体内変化に関する研究(第6報)メチルヘキサビタールの生体内変化 その2 メチルヘキサビタール及びノルメチルヘキサビタールのクロム酸酸化について
- 薬品の生体内変化に関する研究(第2報)Ethylhexabital(5-Cyclo-5-ethylbarbituric Acid)の生体内変化
- 薬品の生体内変化に関する研究(第3報)Methylexabital(5-Cyclohexenyl-3,5-dimethyl-barbituric Acid)の生体内変化 その1
- Biochemical Studies on the Drug Metabolism. II. Inductive Effect of Malonic Acid Derivatives on Cyclobarbital-Metabolizing Enzyme in Rat Liver