Biochemical Studies on the Drug Metabolism. II. Inductive Effect of Malonic Acid Derivatives on Cyclobarbital-Metabolizing Enzyme in Rat Liver
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概要
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Malonic acid derivatives having cyclohexene ring were prepared and their effects on the metabolism of EHB in the rat liver preparation were examined. In the female rats pretreated with cyclohexenylethylmalonamic acid ethyl ester (VI), cyclohexenylethylmalonic acid diamide (VII), 2-cyclohexenyl-2-ethylacetamide (VIII), and cyclohexenylethylacetylurea (IX), the duration of EHB-hypnosis was shortened and the EHB-metabolizing activity of liver homogenate was stimulated. On the other hand, the duration of EHB-hypnosis was prolonged and the metabolizing activity was inhibited by pretreatment with 2-(diethylamino) ethyl cyclohexenylethylacetate hydrochloride (X) or N-[2-(diethylamino) ethyl]-2-cyclohexenyl-2-ethylacetamide oxalate (XI).
- 公益社団法人日本薬学会の論文
- 1964-11-25
著者
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有吉 敏彦
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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高畠 英伍
国立公衆衛生院衛生薬学部
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高畠 英伍
Pharmaceutical Institute Medical Faculty University Of Kyushu
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