Biochemical Studies on the Drug Metabolism. IV. Adaptive Increases in Cyclobarbital-Metabolizing Enzyme Induced by Barbiturate Derivatives

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概要

• 論文の詳細を見る

• Various 1-methyl- and 1,3-dimethybarbiturates were prepared and their stimulatory effect on EHB-metabolism in the rat liver preparation were examined. The pretreatment of female rats with original barbiturates markedly accelerated the EHB-metabolism than that with 1-methylbarbiturates, and 1,3-dimethylbarbiturates treatment had not such a stimulatory effect. It was demonstrated that such stimulatory effect of various N-substituted barbiturates on EHB-metabolism would be related to the substitution of N-position of barbituric acid ring.

• 社団法人日本薬学会の論文
• 1964-11-25

著者

• 有吉 敏彦

  Pharmaceutical Institute, Medical Faculty, University of Kyushu

• 有吉 敏彦

  Faculty Of Pharmaceutical Sciences Nagasaki University

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