銅化合物投与ラット臓器中の銅の分布と必須金属への影響

概要

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The distribution of copper in selected tissues and the metabolic interaction of copper with other essential metals were determined after oral administration of cupric carbonate, basic, and the results were compared with those of cupric sulfate. Male Wistar rats were orally administered for 2,5,and 11 d with 0.5 mmol/kg of cupric compounds. Distribution of copper and change in essential metal levels were quantified by atomic absorption analysis. In the case of cupric carbonate, the copper was much more distributed in tissues, especially in the liver, than in that of cupric sulfate. Copper level increased progressively in mitochondria-lysosomal fraction of the liver in proportion to the period of administration. In the 105000g supernatant fraction, copper was distributed in metallothionein fraction rather than in superoxide dismutase fraction which had been considered as copper storage protein. The administration of cupric compounds resulted in an increase of zinc level in the liver, kidney, and spleen, preferentially in metallothionein fraction of the liver, but it seemed to affect little on iron metabolism.
公益社団法人日本薬学会の論文
1984-04-30