連続液-液分配法/液-固抽出法による香粧品の前処理法の検討界面活性剤含有試料中のパラオキシ安息香酸エステルの定量への応用

概要

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An extraction and clean-up flow system using continuous liquid-liquid partition and a disposable octadecyl silane cartridge was devised for the determination of preservatives in cosmetics. The system was applied to determine p-hydroxybenzoate esters (parabens) in cosmetics such as shampoos, hair rinses, creams, etc. containing surfactants which cause emulsification difficulties in the usual shaking extraction. Parabens were extracted with a steady stream of droplets of diethyl ether from a sample in a glass tube and purified by passing through a Sep-Pak C_<18> cartridge. High performance liquid chromatography was used for the determination. Parabens were separated on a Inertsil ODS column by using methanol-water (2 : 1,v/v) as a mobile phase and detected at 254 nm. The present method was found to be simple and rapid with sufficient accuracy and precision. It was applicable to determine parabens in cosmetics containing surfactants.
公益社団法人日本薬学会の論文
1988-02-28