Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
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概要
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The ether-type PAS-glucuronide was isolated as the acetyl-methyl derivative from the urine of rabbit receiving PAS and the structure was established as methyl (5-acet-amido-2-methoxycarbonylphenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid) uronate, which was chemically synthesized. The structure of m-aminophenyl glucuronide was identified with authentic specimen by means of infrared absorption spectra. It was confirmed by enzymatic hydrolysis that the glucuronides of PAS had the structure of β-D-glucopyranuronoside. The relation of m-aminophenol, m-aminophenyl sulfate, m-aminophenyl glucuronide, ether-type PAS-glucuronide, and PAS was discussed.
- 公益社団法人日本薬学会の論文
- 1959-06-10
著者
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山本 陽
Faculty of Pharmaceutical Sciences, Kumamoto University
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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塚元 久雄
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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山本 陽
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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山本 陽
Faculty Of Pharmaceutical Sciences Kumamoto University
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