Studies on Amino Sugars. I. Preparation of N-Acyl Derivatives of 2-Acetamido-2-deoxy-β-D-glucosylamine
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概要
- 論文の詳細を見る
2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosylamine (IV) was prepared by the hydrogenation of 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosyl azide (III) which was obtained by the treatment of acetochloroglucosamine with NaN_3 in formamide at 85°.IV was characterized by the acetylation as N-acetyl-2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosylamine (VI). IV in tetrahydrofuran or pyridine was condensed in the presence of dicyclohexylcarbodiimide with p-nitrobenzoic acid, isonicotinic acid, aceturic acid, hippuric acid and N-benzyloxycarbonyl glycine to yield the corresponding amides, followed by the removal of the protecting groups. N-(ρ-Aminobenzoyl)2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosylamine was obtained by the hydrogenation of the corresponding p-nitrobenzamido derivative over Adams'catalyst.
- 公益社団法人日本薬学会の論文
- 1965-09-25
著者
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山本 陽
Faculty of Pharmaceutical Sciences, Kumamoto University
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山本 陽
Faculty Of Pharmaceutical Sciences Kumamoto University
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塚本 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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宮下 智恵子
Faculty of Pharmaceutical Sciences, Kyushu University
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宮下 智恵子
Faculty Of Pharmaceutical Sciences Kyushu University
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