Preparation of α-Benzyl N-Benzyloxycarbonyl-DL-aspartate and its Resolution by 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosylamine
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概要
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N-Benzyloxycarbonyl-DL-aspartic acid α-benzyl ester was prepared from N-benzyl-oxycarbonyl-L-aspartic anhydride on racemisation in the prersence of dicyclohexylamine and condensed with 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosylamine to give diastereomeric two glycopeptide acetates, 1-(α-benzyl N-benzyloxycarbonyl-L-β-aspart-amido)-2-acetamido-1,2-dideoxy-3,4,6-tri-O-acetyl-β-D-glucose and 1-(α-benzyl N-benzyloxycarbonyl-D-β-aspartamido)-2-acetamido-1,2-dideoxy-3,4,6-tri-O-acetyl-β-D-glucose. Both compounds were subjected to hydrogenolysis and de-O-acetylation to give the resulting two glycopeptide, N-(L-β-aspartyl)-2-acetamido-2-deoxy-β-D-glucosylamine and N-(D-β-aspartyl)-2-acetamido-2-deoxy-β-D-glucosylamine.
- 公益社団法人日本薬学会の論文
- 1965-09-25
著者
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山本 陽
Faculty of Pharmaceutical Sciences, Kumamoto University
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山本 陽
Faculty Of Pharmaceutical Sciences Kumamoto University
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塚本 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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