Studies on Amino Sugars. II. Preparation of N-[L-α(and β)-Aspartyl]-2-acetamido-2-deoxy-β-D-glucosylamine and N-(L-γ-Glutamyl)-2-acetamido-2-deoxy-β-D-glucosylamine

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N-(L-β-Aspartyl)-2-acetamido-2-deoxy-β-D-glucosylamine has been prepared by the condensation of N-benzyloxycarbonyl-L-aspartic acid α-benzyl ester with 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucosylamine in the presence of dicyclohexylcarbodiimide followed by hydrogenolysis and de-O-acetylation on the resulting 1-(α-benzyl N-benzyloxy-carbonyl-L-β-aspartamido)-2-acetamido-1,2-dideoxy-3,4,6-tri-O-acetyl-β-D-glucose to remove the protecting groups. N-(L-β-Aspartyl)-2-acetamido-2-deoxy-β-D-glucosylamine and N-(L-γ-glutamyl)-2-acetamido-2-deoxy-β-D-glucosylamine have been prepared by the same method as for β-aspartylglycopeptide.
公益社団法人日本薬学会の論文
1965-09-25