Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
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概要
- 論文の詳細を見る
Metabolism of various alkyl p-hydroxybenzoates was investigated in rabbits using oral dose levels of 0.4 and 0.8 g./kg., and compared with than of p-hydroxybenzoic acid, which is a major metabolite of their esters. Metabolism of the esters was very rapid and excretion of the free p-hydroxybenzoic acid in the urine after administration was much less than that of p-hydroxybenzoic acid but output of the acid conjugated with glycine and glucuronic acid was much larger. When various alkyl esters were administered, those were converted into the free acid (25〜39%), glycine conjugate (15〜29%) , ester-type glucuronide (5〜8%), ether-type glucuronide (10〜18%), and the sulfate (7〜12%) during 24 hours.
- 社団法人日本薬学会の論文
- 1964-07-25
著者
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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寺田 精介
Hygienic Research Laboratory of Nagasaki Prefecture
関連論文
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- Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
- Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
- Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
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- Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
- Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
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- Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
- Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.
- Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
- Metabolism of Drugs. XXXVII. The Biotransformation of Drugs having Cyclohexene Ring. (4). The Metabolic Fate of 5-Cyclohexenyl-5-alkylhydantoins.
- Metabolism of Drugs. XXX. The Biotransformation of Drugs having Cyclohexene Ring. (3). The Synthesis and Metabolism of 5-Ethyl-5-(1-cyclohexenyl)-4,6-dioxohexahydropyrimidine.
- Metabolism of Drugs. XXV. Biotransformation of Drugs having Cyclohexene Ring. (2). Metabolic Fate of 2-Substituted Cyclohexenylglutarimides.
- Metabolism of Drugs. XXIV. Biotransformation of Drugs having Cyclohexene Ring. (1). Synthesis of Cyclohexenylglutarimide Derivatives.
- Metabolism of Drugs. XXIII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit.
- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Metabolism of Drugs. XXIX. Metabolic Fate of Meprobamate. (2). Further Studies on the Structure of the Metabolites.
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- Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
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- Enzymatic Oxidation of Methylhexabital
- Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi
- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.