Metabolism of Drugs. XXXVII. The Biotransformation of Drugs having Cyclohexene Ring. (4). The Metabolic Fate of 5-Cyclohexenyl-5-alkylhydantoins.
スポンサーリンク
概要
- 論文の詳細を見る
5-Ethyl-, 5-methyl-5-cyclohexenylhydantions (ECH and MCH), are prepared from the corresponding cyanoacetamide or malonamide using the Hofmann reaction. These 5,5-disubstituted hydantions haveing cyclohexenyl group appear to display narcotic action with 300 mg./kg. in the rabbit. These hydantoins are metabolized to oxo-compounds in the rabbits (about 14.0%), which are identical with the CrO_3-oxidation product of ECH or MCH respectively. It is finally concluded that the biological and chemical oxidation of the drugs having cyclohexenyl group preferentially takes place on the position 3 in the cyclohexenyl group, and the keto formation abolishes the characteristic pharmacologial action of the drugs in animal. Accordingly, this biological oxidation reaction is considered to be significant only as a detoxication mechanism.
- 公益社団法人日本薬学会の論文
- 1963-06-25
著者
-
塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
-
塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
-
吉村 実
長崎大学薬学部
-
吉村 実
Pharmaceutical Faculty University Of Nagasaki
関連論文
- Metabolism of Drugs. XLIII. Comparison of Glucuronyl Transfer Activity between β-Glucuronidase and Uridine Diphosphate Transglucuronylase.
- Metabolism of Drugs. XLII. Isolation of Ester Glucuronides of p-Aminosalicylic Acid and Salicylic Acid from the Urine of Rabbits.
- Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
- Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
- Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
- Metabolism of Drugs. XXXIV. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (2).
- Metabolism of Drugs. XXXIII. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (1).
- Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
- Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
- Metabolism of Drugs. XXVI. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (2).
- p-オキシ安息香酸エステルの体内変化
- Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
- チオウラシル類の分析化学的研究(第2報)チオウラシル類の解離定数およびそれらと過酸化水素の反応について
- Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.
- Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
- チオウラシル類の分析化学的研究(第1報)チオウラシル類の合成と薄層クロマトグラフィー
- Identification of 2,4-Dinitrophenylhydrazones of Volatile Carbonyl Compounds by Combined Gas Chromatography-Mass Spectrometry
- Studies on the Volatile Components of Peated Malt. III. Identification of Acidic and Basic Components
- Studies on the Volatile Components of Peated Malt. II. Identification of Neutral Components
- Studies on the Volatile Components of Peated Malt. I. Identification of Phenolic Compounds
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
- Metabolism of Drugs. XXXVII. The Biotransformation of Drugs having Cyclohexene Ring. (4). The Metabolic Fate of 5-Cyclohexenyl-5-alkylhydantoins.
- Metabolism of Drugs. XXX. The Biotransformation of Drugs having Cyclohexene Ring. (3). The Synthesis and Metabolism of 5-Ethyl-5-(1-cyclohexenyl)-4,6-dioxohexahydropyrimidine.
- Metabolism of Drugs. XXV. Biotransformation of Drugs having Cyclohexene Ring. (2). Metabolic Fate of 2-Substituted Cyclohexenylglutarimides.
- Metabolism of Drugs. XXIV. Biotransformation of Drugs having Cyclohexene Ring. (1). Synthesis of Cyclohexenylglutarimide Derivatives.
- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Metabolism of Drugs. XXIX. Metabolic Fate of Meprobamate. (2). Further Studies on the Structure of the Metabolites.
- Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
- Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
- 薬品の生体内変化に関する研究(第4報)p-Aminosalicylic Acidの家兎における生体内変化 その1
- 放射滴定によるアルカロイドのテトラヨードビスマス酸塩,テトラヨードカドミウム酸塩ならびにテトラヨード水銀酸塩の組成決定
- ガスクロマトグラフィーによるナルコチンおよびパパベリンの熱分解生成物に関する研究
- Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
- Enzymatic Oxidation of Methylhexabital
- Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi
- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.