チオウラシル類の分析化学的研究(第2報)チオウラシル類の解離定数およびそれらと過酸化水素の反応について

概要

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The dissociation constants (pK_1,pK_2) of 6-substituted thiouracils and uracils were determined by the spectrophotometric method. It was found that pK_1 values of thiouracils were lower than those of the corresponding uracils. The effect of substituents in 6-position of these compounds was examined. Amino and phenyl groups, compared with alkyl group, decreases pK_1 values. Further, the reaction of thiouracils with hydrogen peroxide was studied by the reaction kinetics. Thiouracils were finally converted to the corresponding uracils by hydrogen peroxide. Therefore, the first-order reaction constants were determined and the effect of substituents in 6-position of thiouracils was examined. The optimal experimental conditions were established for utilizing the above reaction to the quantitative determination of thiouracils.
公益社団法人日本薬学会の論文
1978-05-25