ピリミジン誘導体の分析化学的研究(第4報)6-アミノ-5-ニトロソ-2-チオウラシル類のS-置換体の鉄およびコバルト錯体について

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Systematic synthesis of S-substituted 6-amino-5-nitroso-2-thiouracils (I-XIII) was performed for the utilization of pyrimidine derivatives as analytical reagents for some metal ions. These thiouracils were found to react easily with iron (II) and cobalt (II) to yield blue and yellow complexes, respectively, which could be extracted with chloroform. The absorption spectra of the complexes in chloroform indicated that III, IV, VI, VII, IX, and XII were potential analytical reagents for iron (II) and cobalt (II). The variation of the alkyl group on the thioxy group exerted no remarkable effect on complex formation. The cobalt (III) complexes of 6-amino-2-benzylthio-5-nitroso-4-oxo-3,4-dihydropyrimidine (ABNP), 6-amino-2-benzylthio-5-nitroso-4-oxo-1-phenyl-1,4-dihydropyrimidine (ABNPP), and 1-nitroso-2-naphthylamine (NNA) were prepared to clarify the structures. The formulas of the isolated complexes are Co (III)・(C_<11>H_9N_4O_2S)_3・H_2O, Co (III)・(C_<17>H_<13>-N_4O_2S)_3・2H_2O, and Co (III)・(C_<10>H_7N_2O)_3,respectively. On the basis of UV, IR, NMR, and magnetic susceptibility measurements, the structures for these compounds were proposed. It may be considered that ABNP, ABNPP, and NNA are coordinated to cobalt (III) through the amino and nitroso group.
公益社団法人日本薬学会の論文
1980-05-25