Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
スポンサーリンク
概要
- 論文の詳細を見る
2. The kinetics of the hydrolysis of 2-naphthyl β-D-glucofuranosiduronic acid by β-glucuronidase were investigated. The pH optimum of the β-D-glucofuranosiduronic acid is 5.0 in phosphate-citrate buffer at 38°. The reaction velocity is constant with time. The Michaelis-Menten constant is 1.75×10^<-2>M. The kinetics of the hydrolysis of 2-naphthyl β-D-glucopyranosiduronic acid by the enzyme were also investigated. The pH optimum is 4.7. The Michaelis-Menten constant is 1.3×10^<-3>M. 3. In view of the above facts, it was concluded that β-D-glucofuranosiduronic acids could be a substrate for β-glucuronidase.
- 社団法人日本薬学会の論文
- 1964-06-25
著者
-
吉田 和夫
Daiichi College Of Pharmaceutical Sciences
-
加藤 敬太郎
九州大学薬学部
-
塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
-
加藤 敬太郎
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
-
吉田 和夫
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
-
Kato Keitaro
Division Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Kyushu University
-
塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
関連論文
- Inhibitory Effect of Ethanol and Colchicine on the Intracellular Processing of β-Glucuronidase Which Occurs in the Golgi Complex
- Chromatography of β-Glucuronidase from Bovine Liver. A Study of the Enzyme Binding Sites of Prepared Adsorbents
- Properties of β-Glucuronidase Bound to p-Aminophenyl 1-Thio-β-D-glucopyranosiduronic Acid-CH-Sepharose 4B
- Possible Role of Cytochrome P-448 in the O-Deethylation of p-Nitrophenetole by Rat Liver Microsomes
- Affinity Chromatography of Rabbit Liver β-Glucuronidase
- Sulfanilamideの代謝物および関連化合物の抗原性に関する実験的研究
- Oxidative Cleavage of the 1,2-Linkage of 2,3-Disubstituted-4 (3H)-quinazolinone with Hydrogen Peroxide
- Syntheses of Halogen Substituted Indolyl β-D-Glucuronides and Their Hydrolysis by Rabbit Liver β-Glucuronidase
- Studies on the Mechanism of Drug Allergy to Sulfanilamides. I. A Colorimetric Method for the Determination of 4-Hydroxylamino-benzenesulfonamide in Biological Materials with Sodium Pentacyanoammineferroate
- 界面活性剤を用いる乳製品中の脂肪定量法(第7報) : バブコック法への界面活性剤の使用
- AlkylおよびAryl HexopyranosideならびにHexofuranosideのマススペクトル
- Transfer Reaction of β-D-Glycofuranose by β-Glycosidase
- Synthesis of β-D-Galactofuranosides and Their Behavior toward β-Galactosidase
- Hydrolysis of Aryl β-D-Glucofuranoside by Almond Emulsin β-Glucosidase
- Metabolism of Drugs. XLIII. Comparison of Glucuronyl Transfer Activity between β-Glucuronidase and Uridine Diphosphate Transglucuronylase.
- Metabolism of Drugs. XLII. Isolation of Ester Glucuronides of p-Aminosalicylic Acid and Salicylic Acid from the Urine of Rabbits.
- Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
- Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
- Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
- Metabolism of Drugs. XXXIV. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (2).
- Metabolism of Drugs. XXXIII. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (1).
- 細胞内取り込み機構で活動するライソゾーム膜糖蛋白質の生化学的研究(発表論文抄録(1989年))
- 細胞内取り込み機構に局在するライソゾーム膜糖蛋白質の形態学的研究(発表論文抄録(1989年))
- ラット肝ライソゾーム膜のシアロ糖蛋白質をコードするcDNAの単離とその配列(発表論文抄録(1989年))
- Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
- Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
- Metabolism of Drugs. XXVI. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (2).
- p-オキシ安息香酸エステルの体内変化
- Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
- ラット腎細胞におけるカテプシンBの局在部位 : 2. Protein A-金法を用いた免疫電子顕微鏡的研究(発表論文抄録(1986年))
- ラット腎細胞におけるカテプシンBの局在部位 : 1. 酵素抗体法を用いた光学顕微鏡的研究(発表論文抄録(1986年))
- ラット肝細胞におけるカテプシンDの局在部位 : 免疫細胞化学的研究(発表論文抄録(1985年))
- ラット腎尿細管におけるカテプシンDの局在部位 : 免疫細胞化学的方法(発表論文抄録(1985年))
- アシドフォスファターゼはライソゾームへ細胞内移行する際,細胞膜を経由しない(発表論文抄録(1990年))
- 培養肝細胞におけるオートファゴゾーム形成膜の免疫電顕による研究(発表論文抄録(1990年))
- Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.
- Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
- チオールプロテアーゼ阻害剤ロイペプチンによる培養肝細胞におけるカテプシンLの細胞内成熟の阻止効果(発表論文抄録(1996))
- ライソゾームのカテプシンDの培養肝細胞における生合成とプロセシング(発表論文抄録(1996))
- リソソームカテプシンB及びHの諸性質とそれらの細胞内プロセシング(発表論文抄録(1996))
- Inhibitory Effect of Leupeptin on the Intracellular Maturation of Lysosomal Cathepsin L in Primary Cultures of Rat Hepatocytes
- Biochemical Properties and Intracellular Processing of Lysosomal Cathepsins B and H
- Biosynthesis and Processing of Lysosomal Cathepsin D in Primary Cultures of Rat Hepatocytes
- カテプシンL前駆体のプロセシングにおけるアスパルティックプロテアーゼの関与について(発表論文抄録(1989年))
- ライソゾーム・カテプシンLの生合成,細胞内プロセシングおよびその活性化(発表論文抄録(1989年))
- J-S9-4 リソソームカテプシンの細胞内プロセシングと活性化
- ラット肝培養細胞におけるリソゾームカテプシンB及びHの生合成(発表論文抄録(1988年))
- ラット肝リソゾーム内容物に存在する酸性ホスファターゼの精製とその性質(発表論文抄録(1988年))
- 細胞生物学からみた生体膜の研究(生体膜研究の展望)
- リソゾーム膜の研究
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
- Metabolism of Drugs. XXXVII. The Biotransformation of Drugs having Cyclohexene Ring. (4). The Metabolic Fate of 5-Cyclohexenyl-5-alkylhydantoins.
- Metabolism of Drugs. XXX. The Biotransformation of Drugs having Cyclohexene Ring. (3). The Synthesis and Metabolism of 5-Ethyl-5-(1-cyclohexenyl)-4,6-dioxohexahydropyrimidine.
- Metabolism of Drugs. XXV. Biotransformation of Drugs having Cyclohexene Ring. (2). Metabolic Fate of 2-Substituted Cyclohexenylglutarimides.
- Metabolism of Drugs. XXIV. Biotransformation of Drugs having Cyclohexene Ring. (1). Synthesis of Cyclohexenylglutarimide Derivatives.
- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Metabolism of Drugs. XXIX. Metabolic Fate of Meprobamate. (2). Further Studies on the Structure of the Metabolites.
- Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
- Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
- 薬品の生体内変化に関する研究(第4報)p-Aminosalicylic Acidの家兎における生体内変化 その1
- Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
- Enzymatic Oxidation of Methylhexabital
- Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi
- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.