Metabolism of Drugs. XIII. The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (5). Further Studies on Isolation, Characterisation, and Identification of Biotransformation Products of the Drug excreted in the Urine of Rabbi
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Additional three metabolites of methylhexabital (MHB, 5-cyclohexenyl-3,5-dimethylbarbituric acid) were isolated from the urine of rabbits receiving MHB and chemical structures of two of these compounds were established as 5-(3-oxo-1-cyclo-hexenyl)-5-methylbarbituric acid and β-5-(3-hydroxy-1-cyclohexenyl)-3,5-dimethyl-barbituric acid. The main metabolites obtained to date were diastereoisomeric 3-OH-MHB[α-and β-5-(3-hydroxy-1-cyclohexenyl)-3,5-dimethylbarbituric acid, in which α-form was considerably predominant]and 3-keto-MHB[5-(3-oxo-1-cyclohexenyl)-3,5-dimethyl-barbituric acid].
- 公益社団法人日本薬学会の論文
- 1957-12-20
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