METABOLIC FATE OF FURAZOLIDONE IN RATS
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概要
- 論文の詳細を見る
The metabolic fate of the widely used veterinary drug, furazolidone (N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone) was examined in rats. When ^<14>C-furazolidone was administered orally to rats, most of the radioactivity was recovered from urine and feces during the first 24 hr, indicating rapid clearance of the nitrofuran from the animal bodies. The radioactivity in feces appears to be partly due to its biliary excretion and partly due to its exsorption. Two metabolites of the nitrofuran were isolated from the urine and unequivocally identified as 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone and N-(5-acetamido-2-furfurylidene)-3-amino-2-oxazolidone by comparison with authentic specimens.
- 公益社団法人日本薬学会の論文
- 1982-09-25
著者
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辰巳 淳
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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高橋 嘉寛
Faculty of Pharmaceutical Sciences, Kumamoto University
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高橋 嘉寛
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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高橋 嘉寛
Faculty Of Pharmaceutical Sciences Kumamoto University
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