Nonspecific Effects of the Selective κ-Opioid Receptor Agonist U-50, 488H on Dopamine Uptake and Release in PC12 Cells
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概要
- 論文の詳細を見る
κ-Opioid receptor agonists decrease the levels of extracellular dopamine in vivo and in vitro. However, the mechanism(s) underlying these actions are unclear. The objective of this study was to distinguish between an effect of the selective κ-opioid receptor agonist U-50,488H ((trans-(±)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl)benzeneacetamide methanesulfonate) on secretion and reuptake of dopamine by PC12 cells. The data show that U-50,488H has both a modest effect to increase dopamine release and a more pronounced effect to inhibit dopamine uptake. Neither effect was sensitive to nor-binaltorphimine or naloxone, suggesting that they are not mediated through an opioid receptor.
- 社団法人 日本薬理学会の論文
- 2003-11-01
著者
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HO Ing
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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Ho Ing
Department Of Pharmacology & Toxicology University Of Mississippi Medical Center
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Ho Ing
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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CHUDAPONGSE Nuannoi
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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KIM Seong-Youl
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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KRAMER Robert
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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Kramer Robert
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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Kim Seong-youl
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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Chudapongse Nuannoi
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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