The Role of Glutamate in Physical Dependence on Opioids
スポンサーリンク
概要
- 論文の詳細を見る
The present review will evaluate the interactions between κ-opioid receptors and glutamate within the locus coeruleus (LC) during the development of opioid dependence and on expression of withdrawal from dependence on opioids. Hyperactivity of noradrenergic neurons in the LC has been proposed to play a critical role in the physiological and behavioral responses that comprise opioid withdrawal. Several studies indicate that the excitatory amino acid system, in particular, glutamate and its receptors, participate in both the withdrawal-associated increase in LC neuronal activity and the expression of opioid withdrawal behaviors. Most studies on opioid dependence have focused on the prototypical opioid morphine, which produces its physical dependence through agonist actions at the μ-opioid receptor. Butorphanol (Stadol®), which exhibits a markedly different profile of opioid receptor activity than does morphine, produces its physical dependence primarily through actions at the κ-opioid receptor. Studies from our laboratories using a rodent model in which butorphanol administration induces dependence indicate further that the κ-opioid receptor is an important regulator of glutamate release within the LC. Glutamate exerts actions within the LC that mediate expression of behavioral symptoms of butorphanol withdrawal.
- 社団法人 日本薬理学会の論文
著者
-
HO Ing
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
-
Ho Ing
Department Of Pharmacology & Toxicology University Of Mississippi Medical Center
-
Zhu Hong
Department Of Materials Science And Engineering Tokyo Institute Of Technology
-
ROCKHOLD Robin
Department of Pharmacology & Toxicology, University of Mississippi Medical Center
-
Rockhold Robin
Department Of Pharmacology & Toxicology University Of Mississippi Medical Center
-
Zhu Hong
Department Of Anatomy Histology & Embryology School Of Basic Medical Sciences Peking University
-
Zhu Hong
Department Of Pharmacology & Toxicology University Of Mississippi Medical Center
関連論文
- Possible Existence of a Novel Receptor for Uridine Analogues in the Central Nervous System Using Two Isomers, N^3-(S)-(+)-and N^3-(R)-(-)-α-Hydroxy-β-phenethyluridines
- Hypnotic Action of N^3-Substituted Arabinofuranosyluracils on Mice
- Synthesis and Central Nervous System Depressant Effects of N^3-Substituted 2', 3'-O-Isopropylideneuridines
- Pharmacologica Efects in Mice of Anandamide and Its Related Fatty Acid Ethanolamides, and Enhancement of Cataleptogenic Effect of Anandamide by Phenylmethylsulfonyl Fluoride
- Preparation of BST Ferroelectric Thin Film by Metal Organic Decomposition for Infrared Sensor
- Application of Ferroelectric BST Thin Film Prepared by MOD for Uncooled Infrared Sensor of Dielectric Bolometer Mode (特集:強誘電体薄膜材料とプロセス技術)
- Compertitive Inhibition of Δ^8-Tetrahydrocannabinol and Its Active Metabolites for Cannabinoid Receptor Binding
- STRUCTURE-ACTIVITY RELATIONSHIP OF URIDINE DERIVATIVES FOR HYPNOTIC ACTIVITY
- Potentiating Effects of N^1,N^3-Diallyluracil, N^1,N^3-Diallylthymine and N^1,N^3-Diallyl-6-methyluracil on Pentobarbital-Induced Sleep and Diazepam-Induced Motor Incoordination(Pharmacological,Chemical)
- Potentiation of Barbiturate-Induced Narcosis by N,N'-(or N,S-) Diallyl-Substituted Derivatives of Phenobarbital, Amobarbital and Thiopental in Mice(Pharmacological)
- Tear Toughness Evaluation of a Permanent Mold Cast A356 Aluminum Alloy Using a Small-size Specimen
- Tear Toughness of Permanent Mold Cast and DC Cast A356 Aluminum Alloys
- EXCITATORY AMINO ACIDS AND LEAD-INDUCED NEUROTOXICITY
- ROLES OF μ-OPIOID RECEPTORS IN DEVELOPMENT OF TOLERANCE TO DIISOPROPYLFLUOROPHOSPHATE (DFP)
- DIFFERENTIAL MODULATION OF MUSCARINIC RECEPTORS IN THE RAT BRAIN BY REPEATED EXPOSURE TO METHYL PARATHION
- MECHANISM OF TOLERANCE DEVELOPMENT TO PHENCYCLIDINE IN RELATION TO GABA-ERGIC NEURONAL AND DISPOSITIONAL FUNCTIONS IN MICE
- Nonspecific Effects of the Selective κ-Opioid Receptor Agonist U-50, 488H on Dopamine Uptake and Release in PC12 Cells
- Butorphanol : Effects of a Prototypical Agonist-Antagonist Analgesic on κ-Opioid Receptors
- The Role of Glutamate in Physical Dependence on Opioids
- Annealing effects on conductivity and microwave dielectric loss of MgTiO3 ceramics
- P2-74 Morphology investigation on the thyroid from autopsies of patients with Severe Acute Respiratory Syndrome (SARS)
- Comparison of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for retrieval of choledocholithiasis : a meta-analysis of randomized controlled trials
- Effects of Barbiturates on GABA System: Comparison to Alcohol and Benzodiazepines.