Synthesis and Central Nervous System Depressant Effects of N^3-Substituted 2', 3'-O-Isopropylideneuridines
スポンサーリンク
概要
- 論文の詳細を見る
N^3-Substituted derivatives of 2', 3'-O-isopropylideneuridine (1) were synthesized and their pharmacological effects on the central nervous system (CNS) examined using mice. Methyl (2), ethyl (3), propyl (4), butyl (5), allyl (6), benzyl (7), o-, m-, p-xylyls (8,9,10), and α-phenylethyl (11) derivatives of 1 were administered to mice by intracerebroventricular (i.c.v.) injection for evaluating hypnotic activity, pentobarbital-induced sleep prolongation, and spontaneous activity as indices. Only 3 possessed hypnotic activity by i.c.v. injection at the dose of 2.0 μmol/mouse. Compounds 3,4,and 10 significantly showed synergism with a barbiturate, indicating that the derivatives have some CNS depressant effects. Moreover, 3 and 4 caused decrease in the spontaneous activity of mice, even at low doses. The present study indicated that substitution by ethyl, propyl, and p-xylyl groups at the N^3-position of 2', 3'-O-isopropylideneuridine imparted the CNS depressant effects.
- 社団法人日本薬学会の論文
- 1999-12-15
著者
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景山 節
京大・霊長類研・生化学
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Yamamoto Ikuo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W
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Watanabe Kazuhito
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Yamamoto Ikuo
Faculty of Education, Yokohama National University
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Kondo Shigemi
Nissui Pharmaceutical Co. Ltd.
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WATANABE Kazuhito
Faculty of Pharmaceutical Sciences, Hokuriku University
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KIMURA Toshiyuki
Faculty of Pharmaceutical Sciences, Hokuriku University
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YAMAMOTO Ikuo
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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HO Ing
University of Mississippi Medical Center
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HO Ing
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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YAO Che
Faculty of Pharmaceutical Sciences, Hokuriku University
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Yamamoto Ikuo
北陸大学 薬 衛化
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YAMAMOTO IKUO
Hygienic Chemistry
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Kimura T
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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景山 節
京都大学霊長類研究所人類進化モデル研究センター
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景山 節
京大・霊長研
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Ho Ing
ミシシッピ大学医学部薬毒理学教室
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Watanabe Kazuhito
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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Kimura Toshiyuki
Faculty Of Engineering Yokohama National University
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Ho Ing
Department Of Pharmacology & Toxicology University Of Mississippi Medical Center
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Yao Che
Faculty Of Pharmaceutical Sciences Hokuriku University:(present Address)faculty Of Chemistry Suzhou
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Kondo S
Kyoritsu Coll. Pharmacy Tokyo Jpn
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Yamamoto I
Hokuriku Univ. Kanazawa Jpn
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto I
Hygienic Chemistry
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Ikuo
Hygienic Chemistry School Of Pharmacy Hokuriku University
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Yamamoto Ikuo
Faculty Of Education Yokohama National University
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Kimura T
Peptide Inst. Inc. Minoh Jpn
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