Conventional Synthesis of Amphiphilic Block Copolymer Utilized for Polymeric Micelle by Mechanochemical Solid-State Polymerization

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概要

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• The first example is presented here of an amiphiphilic block copolymer synthesized by mechanochemical solid-state polymerization and used to form polymeric micelles. A model amphiphilic block copolymer was synthesized first, possessing galactose as a hydrophilic side chain and theophylline as a hydrophobic side chain, by mechanochemical solid-state polymerization. The resulting copolymer had a narrow molecular weight distribution. Polymeric micelle formation was subsequently carried out with the copolymer by a dialysis method. To gain insight into the physicochemical properties of the polymeric micelle, dynamic light scattering (DLS) measurements were performed. A narrow distribution of diameters was observed in the polymeric micelle solution, and these micelles were disrupted by the addition of sodium dodecyl sulfate (SDS). It was also confirmed by DLS measurements that the polymeric micelles were spherical. These results suggested that the block copolymer synthesized by mechanochemical solid-state polymerization was as suitable for the preparation of polymeric micelles as materials obtained by living polymerization.

• 公益社団法人日本薬学会の論文
• 2007-03-01

著者

• 葛谷 昌之

  Matsuyama Univ. Ehime Jpn

• Kondo S

  Hoechst Japan Co. Ltd.

• 近藤 修二

  Hoechst Japan Co. Ltd.

• Kondo Shigemi

  Nissui Pharmaceutical Co. Ltd.

• KONDO Shin-ichi

  Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University

• SASAI Yasushi

  Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University

• 笹井 泰志

  岐阜薬科大学

• MORI Hisato

  Laboratory of Pharmaceutical Physical Chemistry, Gifit Pharmaceutical University

• KUZUYA Masayuki

  Laboratory of Pharmaceutical Physical Chemistry, Gifit Pharmaceutical University

• Kondo S

  Ntt Photonics Laboratories

• Mori Hisato

  Laboratory Of Pharmaceutical Physical Chemistry Gifit Pharmaceutical University

• Kondo S

  Kyoritsu Coll. Pharmacy Tokyo Jpn

• Kondo Shin-ichi

  Dep. Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical Univ.

• Kuzuya Masayuki

  Laboratory Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical University

• Sasai Yasushi

  Gifu Pharmaceutical Univ. Gifu Jpn

• 近藤 伸一

  岐阜薬科大学

• Kondo Shin-ichi

  Laboratory of Pharmaceutical Physical Chemistry, Department of Drug Delivery Technology and Science, Gifu Pharmaceutical University

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