A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VII. Controlled Release of Theophylline from Plasma-Irradiated Polymer-Coated Granules

概要

論文の詳細を見る
With a view to expanding the application of a drug delivery sysetm (DDS) preparation using plasma-irradiated pharmaceutical aids for various dosage forms, we studied the theophylline release property from plasma-irradiated polymer-coated granules, the polymers of which differ in the plasma irradiation effect. We used a new type of rotational plasma-irradiation reactor to perform plasma-irradition uniformly on the surface of polymer-coated granules based on scanning electron microscope (SEM) observation. It was shown that an increase in theophylline release rate with an increase in plasma duration was observed in all polymer-coated granules, although the factors of such release propertis vary with the polymers, as evidenced by the SEM observations. Such results provided the criteria for selecting polymer structures for granule coating. Thus, the present method for the control of drug release is considered principally applicable not only to polymer-coated granules but also to various drug forms under consideration of the above criteria.
公益社団法人日本薬学会の論文
1996-06-15