A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VIII. Delayed-Release of Theophylline from Double-Compressed Tablet Composed of Eudragit as Wall Material
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概要
- 論文の詳細を見る
The rapid release from a double-compressed tablet containing theophylline as a core drug with the pH-dependent water-soluble polymers, Eudragit L100, S100 or L100-55 used as a wall material was suppressed by argon plasma-irradiation due to an effect of inter-segmental cross-link reactions on the decrease in the surface polymer solubility of outer layer. In addition, the rapid theophylline release from the double-comperssed tablet of Eudragit L100-55 with a lower glass transition temperature(T_g)has converted into the delayed-release system under a set of plasma operational conditions due to an additional effect of plasma heat flux on softening of Eudragit L100-55 surface resulting in the formation of the film-like surface with a particle-particle interlinking of the outer layer.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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葛谷 昌之
Matsuyama Univ. Ehime Jpn
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Kondo Shigemi
Nissui Pharmaceutical Co. Ltd.
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KONDO Shin-ichi
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University
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KUZUYA Masayuki
Laboratory of Pharmaceutical Physical Chemistry, Gifit Pharmaceutical University
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Kondo S
Kyoritsu Coll. Pharmacy Tokyo Jpn
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Ito K
Janssen Pharmaceutical K.k. Shizuoka Jpn
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Kondo Shin-ichi
Dep. Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical Univ.
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ITO Kousuke
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University
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MAKITA Yoshimitsu
Pharmaceutical & Technology Laboratory, Sanwa Kagaku Kenkyusho Co.Ltd.
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Kuzuya Masayuki
Laboratory Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical University
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Makita Y
Pharmaceutical & Technology Laboratory Sanwa Kagaku Kenkyusho Co.ltd.
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Kondo Shin-ichi
Laboratory of Pharmaceutical Physical Chemistry, Department of Drug Delivery Technology and Science, Gifu Pharmaceutical University
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