病院・薬局処方で粉砕される市販錠剤からのラジカルの生成

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概要

• 論文の詳細を見る

• We examined mechanoradical formation in the grinding process of commercial tablets using electron spin resonance (ESR). Mechanoradicals were detected in all tested samples (23 types of commercial tablets) when the ballmilling of tablets was conducted under anaerobic conditions and some were fairly stable even in air. Thus the grinding may cause changes in the physicochemical properties of ingredients included in commercial tablets. Because high quality is demanded in pharmaceuticals, these results suggest more caution should be taken in the grinding of commercial tablets in hospitals and pharmacies.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• 近藤 伸一

  岐阜薬科大学放射化学研究室

• 葛谷 昌之

  Matsuyama Univ. Ehime Jpn

• Kondo S

  Hoechst Japan Co. Ltd.

• 近藤 修二

  Hoechst Japan Co. Ltd.

• Kondo Shigemi

  Nissui Pharmaceutical Co. Ltd.

• 笹井 泰志

  岐阜薬科大学

• 葛谷 昌之

  岐阜薬科大学薬品物理化学教室

• 石川 敬章

  岐阜薬科大学薬品物理化学教室

• 古田 陽司

  岐阜薬科大学薬品物理化学教室

• 荒巻 秀樹

  岐阜薬科大学薬品物理化学教室

• 山内 行玄

  岐阜薬科大学薬品物理化学教室

• Kondo S

  Ntt Photonics Laboratories

• Kondo S

  Kyoritsu Coll. Pharmacy Tokyo Jpn

• Kondo Shin-ichi

  Dep. Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical Univ.

• Kuzuya Masayuki

  Laboratory Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical University

• Sasai Yasushi

  Gifu Pharmaceutical Univ. Gifu Jpn

• 近藤 伸一

  岐阜薬科大学

• 山内 行玄

  松山大学

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