新規なメカノケミカル固相重合による高分子プロドラッグの設計と開発に関する研究
スポンサーリンク
概要
- 論文の詳細を見る
The mechanochemical polymerization of solid-state monomer was first reported in 1959. Nevertheless, relatively little work has been done. We reported the first in-depth study of the mechanochemical polymerization of specially synthesized solid-state monomers, methacryloyl derivatives of bioactive compounds including detailed mechanistic implications. There are many advantages for this reaction. One of the most striking properties observed in the resulting polymers is that these polymeric prodrugs are of very low heterogeneity (narrow molecular weight distribution) which is of great value in pharmaceuticals for highly functionalized polymeric prodrugs. Thus, the present reaction provides a novel and simple methodology for the syntheses of highly functionalized polymeric prodrugs through a totally dry process. The nature of drug release from many kinds of polymeric prodrugs prepared by mechanochemical polymerization was also investigated. The rate of drug release from the polymeric prodrugs can be controlled by the property of comonomer and the structure of spacer between the main chain of polymer and drug. Several applications of polymeric prodrugs (chemoembolization and hybrid polymeric prodrugs) were also described. We have carried out the mechanochemical polymerization in the presence of pharmaceutical aids to exploit the features of this reaction. If one takes the physicochemical property of pharmaceutical aids into consideration, novel composite polymeric prodrugs possessing a variety of rates of drug release can be synthesized simultaneously with mixing.
- 公益社団法人日本薬学会の論文
- 2000-12-01
著者
-
近藤 伸一
岐阜薬科大学放射化学研究室
-
Kondo Shigemi
Nissui Pharmaceutical Co. Ltd.
-
Kondo S
Kyoritsu Coll. Pharmacy Tokyo Jpn
-
Kondo Shin-ichi
Dep. Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical Univ.
-
近藤 伸一
岐阜薬科大学
関連論文
- Effect of annealing on DLC characteristics by ESR spectral analysis
- Studies on the Granulation Process of Granules for Tableting with a High Speed Mixer. I. Physical Properties of Granules for Tableting
- P-057 エタノールによる標的臓器での代謝活性化の促進作用(ポスターセッション)
- Possible Existence of a Novel Receptor for Uridine Analogues in the Central Nervous System Using Two Isomers, N^3-(S)-(+)-and N^3-(R)-(-)-α-Hydroxy-β-phenethyluridines
- Hypnotic Action of N^3-Substituted Arabinofuranosyluracils on Mice
- A Carbonyl Reductase-Catalyzing Reduction of N^3-Phenacyluridine in Rabbit Liver
- Synthesis and Central Nervous System Depressant Effects of N^3-Substituted 2', 3'-O-Isopropylideneuridines
- Synthesis and Sedative-Hypnotic Effects of N^3-Allyl-and N^1-Allyl-5,6-substituted 2-Thiouracil Derivatives in Mice
- 砂糖ラジカル測定による東海村臨界事故の放射線被曝の推定
- Plasma surface modification of polymer substrate for cell adhesion control
- Activity evaluation of antibody immobilized onto the self-assembled phospholipid layer fabricated by plasma-assisted method
- Immobilization of bioactive molecule onto polymer surface functionalized by plasma techniques and its application to cell culture
- Plasma-assisted fabrication of self-assembled phospholipid layer onto polymer surface and its characterization
- Plasma-Assisted Immobilization of Heparin onto Low-Density Polyethylene Surface
- 4. プラズマ製薬(医療バイオ分野へのプラズマ応用)
- Conventional Synthesis of Amphiphilic Block Copolymer Utilized for Polymeric Micelle by Mechanochemical Solid-State Polymerization
- プラズマ技法による乾式DDS開発
- Preparation of Floating Drug Delivery System by Plasma Technique
- Immobilization of Antithrombotic Biomolecules on LDPE Surface Functionalized by Plasma Techniques
- Synthesis of DNA Conjugate by Mechanochemical Solid-State Polymerization and Its Affinity Separation of Oligonucleotides Having Single-Base Difference by Capillary Electrophoresis
- 病院・薬局処方で粉砕される市販錠剤からのラジカルの生成
- Mechanochemical Solid-State Polymerization (XI) : Effect of Water-Insoluble Pharmaceutical Aids on Drug Release from Mechanically Synthesized Polymeric Prodrugs
- Novel and Simple Preparation Method of Matrix-Type Composite Particles for Controlled Drug Release by Mechanical Action
- Nature of Mechanoradical Formation of Substituted Celluloses as Studied by Electron Spin Resonance
- ステンレス製容器を用いたメカノケミカル固相反応によるリボフラビンラジカルの生成
- 「日向天照水」の分析と評価
- Peroxy Radical Formation from Plasma-induced Surface Radicals of Polyethylene as Studied by Electron Spin Resonance.
- Plasma-induced Surface Radicals of Low Density Polyethylene(LDPE) Studied by Electron Spin Resonance.
- Nature of Auto-oxidations on Plasma-induced Surface Radicals of Aromatic Ring-containing Polymers as Studied by Electron Spin Resonance.
- Nature of Auto-oxidations on Plasma-induced Surface Radicals of Polyethylene Studied by Electron Spin Resonance.
- Plasma-induced Surface Radicals of Low Density Polyethylene Studied by Electron Spin Resonance.
- Special Features of Peroxy Radicals on Plasma-Irradiated Polymers.
- Nature of Auto-Oxidations on Plasma-Induced Surface Radicals of Polyethylene Studied by Electron Spin Resonance
- Special Features of Peroxy Radicals on Plasma-irradiated Polymers
- ESR Study on the Nature of Oxygen Plasma-Induced Surface Radicals of Teflon and Corresponding Peroxy Radical Reactivity.
- プラズマ照射した医薬品助剤を利用する新規なドラッグデリバリーシステムの開発 : 第10報 スチレン-(無水)マレイン酸共重合体を外層高分子とした二重錠剤へのプラズマ照射によるテオフィリンの放出制御
- プラズマ技術を用いる新規DDSの開発 (特集 健康の維持と増進を科学する--疫病を克服し、もっと健康に)
- Central Nervous System Depressant Effects of N^3-Substituted Derivatives of Deoxyuridine in Mice
- Preparation of Floating Drug Delivery System by Pulsed-Plasma Techniques
- Plasma-Assisted Immobilization of Bio-Molecules on LDPE Surface
- Synthesis of Water-Soluble Polymeric Prodrugs Possessing 4-Methylcatechol Derivatives by Mechanochemical Solid-State Copolymerization and Nature of Drug Release
- Introduction of Durable Hydrophilicity on Nylon12 by Plasma Treatment.
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. IX. : Controlled-Release of Theophylline from Double-Compressed Tablet Composed of Cellulose Derivatives as Wall Material.
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VIII. : Delayed-Release of Theophylline from Double-Compressed Tablet Composed of Eudragit as Wall Material.
- Estimation of Radiation Exposed Area by the Nuclear Accident Occurred at Tokai Village Using ESR Measurements of Household Sugar.
- Preparation of Floating Drug Delivery System by Plasma Techniques
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. IX. Controlled-Release of Theophylline from Double-Compressed Tablet Composed of Cellulose Derivatives as Wall Material
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VIII. Delayed-Release of Theophylline from Double-Compressed Tablet Composed of Eudragit as Wall Material
- Mechanochemical Solid-State Polymerization (X) : The Influence of Copolymer Structure in Copolymeric Prodrugs on the Nature of Drug Release.
- Mechanochemical Solid-State Polymerization (X) : The Influence of Copolymer Structure in Copolymeric Prodrugs on the Nature of Drug Release
- Mechanolysis of Glucose-Based Polysaccharides As Studied by Electron Spin Resonance.
- Specificites in Structures of Surface Radicals on Substituted Celluloses Produced by Plasma-irradiation.
- Plasma-Induced Free Radicals of Polycrystalline Carbohydrate as Spin Probe for Plasma Diagnosis of Plasma Treatment.
- プラズマの新しい医薬品工学への応用
- Mechanochemical Solid-state Polymerization. IX. : Thoretical Analysis of Rate of Drug Release from Powdered Polymeric Prodrugs in a Heterogeneous System.
- Mechanochemical Solid-state Polymerization. VIII. : Novel Composite Polymeric Prodrugs Prepared by Mechanochemical Polymerization in the Presence of Pharmaceutical Aids.
- Specificities in Structures of Surface Radicals on Substituted Celluloses Produced by Plasma-irradiation
- Mechanochemical Solid-State Polymerization. IX. Theoretical Analysis of Rate of Drug Release from Powdered Polymeric Prodrugs in a Heterogeneous System
- The Syntheses of Novel Hybrid Polymeric Prodrugs Prepared by Mechanochemical Polymerization and the Nature of their Drug Release.
- Mechanochemical Solid-State Polymerization. VIII. Novel Composite Polymeric Prodrugs Prepared by Mechanochemical Polymerization in the Presence of Pharmaceutical Aids
- メカノケミカル固相重合による新規ハイブリッド型高分子プロドラッグの構築とその薬物放出特性
- Effect of Alkyl Substituent on Plasma-Induced Freee Radicals of Cellulose Derivatives.
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VII. : Controlled Release of Theophylline from Plasma-Irradiated Polymer-Coated Granules.
- A Novel Collision-Induced Solid State Radical Recombination.
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VI. : Controlled Release of Theophylline from Plasma-Irradiated Double-Compressed Tablet Composed of Water-Soluble Poymers as a Wall Material.
- Spectrochemistry of Plasma-Induced Free Radicals in Cellulose Derivatives.
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VII. Controlled Release of Theophylline from Plasma-Irradiated Polymer-Coated Granules
- A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VI. Controlled Release of Theophylline from Plasma-Irradiated Double-Compressed Tablet Composed of Water-Soluble Polymers as a Wall Material
- Spectrochemistry of Plasma-Induced Free Radicals in Cellulose Derivatives
- Mechanochemical Reactions of Plasma-Induced Surface Radicals on Polyethylene.
- Quantum Chemical Rationale on Free-Radical Formation of Irradiated Acrylic Polymers.
- Molecular Orbital Study on Photoreaction of Peroxy Radicals of Polytetrafluoroethylene.
- Mechanochemical Solid-State Polymerization. VII. The Nature of Hydrolysis of Novel Polymeric Prodrugs Prepared by Mechanochemical Copolymerization
- Quantum Chemical Study on Conformational Properties of Bipyridine Cardiotonics.
- Mechanochemical Solid-State Polymerization. VI. Quantum Chemical Considerations for Structural Criteria of Mechanically Polymerizable Vinyl Monomers
- Molecular Orbital Study on Photoreaction of Peroxy Radicals of Polytetrafluoroethylene
- Quantum Chemical Study on Conformational Properties of Bipyridine Cardiotonics
- メタクリル酸とそのn-アルキルエステル類との共重合反応性
- ヒドロキシアントラキノン誘導体を含有する天然医薬品のメカノケミカル固相反応
- Immobilization of proteins onto the self-assembled phospholipid layer fabricated by plasma-assisted method
- 新規なメカノケミカル固相重合による高分子プロドラッグの設計と開発に関する研究
- 低温プラズマを用いたバイオマテリアルの表面機能化 (特集 プラズマと人間環境保全)
- Evaluation on Fluidity of the Self-Assembled Phospholipid Layer Fabricated by Plasma-Assisted Method and its Application
- Characterization of Novel pH-Sensitive Polymeric Micelles Prepared by the Self-Assembly of Amphiphilic Block Copolymer with Poly-4-vinylpyridine Block Synthesized by Mechanochemical Solid-State Polymerization
- 低温プラズマを用いたバイオマテリアルの表面機能化