A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. IX. Controlled-Release of Theophylline from Double-Compressed Tablet Composed of Cellulose Derivatives as Wall Material

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概要

• 論文の詳細を見る

• The rapid release from a double-comperssed tablet containing theophylline with the water-soluble polymer, hydroxypropylmethylcellulose(HPMC) or hydroxypropylmethylcellulose phthalate(HPMCP), used as a wall material can be supperssed by argon plasma-irradiation and changed into the sustaine-release system due to a decrease in solubility of the outer layer. It was shown that the release profiles can be varied so as to cause theophylline release at different rates, depending on the set of conditions chosen for tablet manufacture and for plasma operation.

• 公益社団法人日本薬学会の論文
• 2001-12-01

著者

• 葛谷 昌之

  Matsuyama Univ. Ehime Jpn

• Kondo Shigemi

  Nissui Pharmaceutical Co. Ltd.

• KONDO Shin-ichi

  Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University

• KUZUYA Masayuki

  Laboratory of Pharmaceutical Physical Chemistry, Gifit Pharmaceutical University

• Kondo S

  Kyoritsu Coll. Pharmacy Tokyo Jpn

• Ito K

  Janssen Pharmaceutical K.k. Shizuoka Jpn

• Kondo Shin-ichi

  Dep. Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical Univ.

• ITO Kousuke

  Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University

• Kuzuya Masayuki

  Laboratory Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical University

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