A Nitroimidazole Derivative, PR-350, Enhances the Killing of Pancreatic Cancer Cells Exposed to High-dose Irradiation under Hypoxia

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概要

• 論文の詳細を見る

• The radiosensitizing effects of PR-350, a nitroimidazole derivative, were examined concerning the cell killing of human pancreatic cancer cell lines exposed to high doses of gammaray irradiation in vitro. The percentages of dead cells were analyzed with a multiwell plate reader to measure the fluorescence intensity of propidium iodide before and after a digitonin treatment. The sensitizing effect of PR-350 on cell killing by high-dose irradiation was confirmed by time-course, dose-dependency, and microscopic observations. In five of seven pancreatic cancer cell lines in which the number of dead cells was determined 5 days after 30 Gy irradiation in the presence of PR-350, the number was significantly increased under hypoxic conditions, but not under aerobic conditions. The selective radiosensitive effect of PR-350 on hypoxic cells was also confirmed by flow cytometry. The results indicate that PR-350 can enhance the killing of pancreatic cancer cells by high-dose irradiation under hypoxia, which supports its clinical radiosensitizing effects when administered during intraoperative irradiation to pancreatic cancer.

• 日本放射線影響学会の論文

著者

• ZHANG Li

  Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force

• Katano Mitsuo

  Department Of Cancer Therapy And Research Graduate School Of Medical Sciences Kyushu University

• Kusumoto Masahiro

  Department Of Cancer Therapy And Research Graduate School Of Medical Sciences Kyushu University

• MIZUMOTO Kazuhiro

  Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University

• TANAKA Masao

  Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University

• Mizumoto Kazuhiro

  九州大学 医学研究院臨床腫瘍外科学

• Mizumoto Kazuhiro

  Cancer Center Kyushu University

• Tanaka M

  Department Of Surgery And Oncology Graduate School Of Medical Sciences Kyushu University

• Kawamoto Masahiko

  オーストラリア

• Kawamoto Masahiko

  Department Of Surgery And Oncology Graduate School Of Medical Sciences Kyushu University

• Takashima Masaki

  九州大学 第1外科

• QIAN LI-WU

  Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University

• NAGAI EISHI

  Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University

• KURA SHINOBU

  Institute of Experimental Radiology, Graduate School of Medical Sciences, Kyushu University

• Masatsugu Toshihiro

  九州大学 医学系研究院 臨床腫瘍外科

• Qian Li-wu

  九州大学 医研究院 臨床腫瘍外科

• Qian Li-wu

  Department Of Surgery And Oncology Graduate School Of Medical Sciences Kyushu University

• Kura Shinobu

  九州大学 医研究院 臨床腫瘍外科

• Kura Shinobu

  Institute Of Experimental Radiology Graduate School Of Medical Sciences Kyushu University

• Kura Shinobu

  Institute Of Experimental Radiology Graduate School Of Medical Sciences

• Nagai E

  Wakamatsu Municipal Hospital Kitakyushu Jpn

• Nagai Eishi

  北九州市立若松病院

• Nagai Eishi

  Department Of Surgery And Oncology Graduate School Of Medical Sciences Kyushu University

• Nagai Eishi

  九州大学 医研究院 臨床腫瘍外科

• Nagai Eishi

  九州大学 第2病理

• Nagai Eishi

  Division Of Surgery Wakamatsu Municipal Hospital

• Mizumoto Kazuhiro

  Department Of Anesthesiology Wakayama Medical University School Of Medicine

• Tanaka Masao

  Department Of Surgery And Oncology Graduate School Of Medical Sciences Kyushu University

• Zhang Li

  Department Of Biochemistry And Molecular Biology College Of Life Science Nanjing Agricultural Univer

• Tanaka Masao

  Department Of Hematology And Immunology Kanazawa Medical University

• Takashima Masaki

  Departments Of Pathology Ii Kyushu University Faculty Of Medicine

• Zhang Li

  Department Of Surgery And Oncology Graduate School Of Medical Sciences Kyushu University

• Tanaka Masao

  Department Of Endoclinology Noguchi Thyroid Clinic And Hospital Foundation

• Tanaka Masao

  Department Of Biology Faculty Of Science Kyushu University

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