In Vitro Evaluation of Topical Microemulsion of Capsaicin Free of Surfactant(Miscellaneous)
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概要
- 論文の詳細を見る
Topical microemulsion of capsaicin without surfactant was developed in this study. In these systems, the oil phase was benzyl alcohol, and the cosurfactant was propylene glycol and ethanol. The drop-size of the systems was measured by dynamic light scattering method in order to distinguish true solution from microemulsion. The transdermal performance of the microemulsions was evaluated in vitro by Franz diffusion cells fitted with rat skins. The results showed the drop-size of the microemulsions without surfactant was smaller than that of the systems with Tween 80 and the permeation rate of capsaicin decreased as the content of Tween 80 increased. In the system composed of water, benzyl alcohol and propylene glycol, the permeation rate increased with the enhancement of benzyl alcohol and water. But water content had little effect on the permeation rate in the microemulsions with ethanol as cosurfactant.
- 2008-12-01
著者
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ZHANG Pengwei
School of Pharmaceutical Science and Technology, Tianjin University
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GAO Wenyuan
School of Pharmaceutical Science and Technology, Tianjin University
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ZHANG Li
Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force
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CHEN Li
Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force
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SHEN Qufei
Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force
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WANG Xiaohui
Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force
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CUI Ying
Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force
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Cui Ying
Department Of Pharmaceutics Medical College Of Chinese People's Armed Police Force
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Shen Qufei
Department Of Pharmaceutics Medical College Of Chinese People's Armed Police Force
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Gao Wenyuan
School Of Pharmaceutical Science And Technology Tianjin University
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Wang Xiaohui
Department Of Materials Science And Engineering Tsinghua University
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Wang Xiaohui
Department Of Pharmaceutics Medical College Of Chinese People's Armed Police Force
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Zhang Pengwei
School Of Pharmaceutical Science And Technology Tianjin University
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Chen Li
Department Of Electrical And Electronic Engineering Akita University
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Zhang Li
Department Of Biochemistry And Molecular Biology College Of Life Science Nanjing Agricultural Univer
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Cui Ying
Department Of Pathology Wonju College Of Medicine Yonsei University
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Chen Li
Department Of Pharmaceutics Medical College Of Chinese People's Armed Police Force
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Chen Li
Department Of Chemistry Pukyong National University
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Zhang Li
Department Of Pharmaceutics Medical College Of Chinese People's Armed Police Force
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Cui Ying
Department Of Chemistry Harbin Institute Of Technology
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