Doxorubicin-Loaded Zein in Situ Gel for Interstitial Chemotherapy
スポンサーリンク
概要
- 論文の詳細を見る
A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.
著者
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Xu Qian
Department Of Orthopaedic Surgery The First Affiliated Hospital Of Guangzhou Medical College
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Zhang Li
Department Of Biochemistry And Molecular Biology College Of Life Science Nanjing Agricultural Univer
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Cao Xiaoying
Department of Pharmacy, Hebei University of Science and Technology
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Geng Jianning
Department of Pharmacy, Hebei University of Science and Technology
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Su Suwen
Department of Pharmacology, Hebei Medical University
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Zhang Linan
Department of Pharmacy, Hebei University of Science and Technology
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Xie Yinghua
Department of Pharmacy, Hebei University of Science and Technology
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Wu Shaomei
Department of Pharmacy, Hebei University of Science and Technology
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Sun Yongjun
Department of Pharmacy, Hebei University of Science and Technology
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Gao Zibin
Department of Pharmacy, Hebei University of Science and Technology
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Xu Qian
Department of CT, the Forth Hospital of Hebei Medical University
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Zhang Li
Department of Pharmaceutics, New Drug Research and Development Center, North China Pharmaceutical Group Corporation
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