Retigeric Acid B Enhances the Efficacy of Azoles Combating the Virulence and Biofilm Formation of Candida albicans
スポンサーリンク
概要
- 論文の詳細を見る
Candida albicans is one of the most prevalent human opportunistic pathogens. C. albicans undergoes a yeast-to-hyphal transition that has been identified as a virulence factor as well as a critical element for mature biofilm formation. A previous study in our lab showed retigeric acid B (RAB), a lichen derived pentacyclic triterpenoid, displayed synergistic antifungal activity with azoles. We now showed that this combination also proved to be adequate in combating the formation of hyphae in vitro. In vivo tests with mice demonstrated RAB could markedly enhance the efficacy of fluconazole to promote the host’s longevity through inhibiting hyphae formation and adherence to host cells. It was also observed that RAB and azoles interacted synergistically to block the formation of biofilm. Our data suggested the attenuated yeast-to-hyphal switch contributed to the defect of mature biofilm formation. Moreover, quantitative real-time polymerase chain reaction (qPCR) analysis showed RAB could reduce the transcript level of MDR1, a multidrug efflux pump, and caused a slight transcriptional reduction for another drug pump related gene CDR1. Taken together, our work provides a potential application to combat candidiasis using the combination of RAB and azoles.
著者
-
Zhang Li
Department Of Biochemistry And Molecular Biology College Of Life Science Nanjing Agricultural Univer
-
Liu Yongqing
Department Of Metallurgy College Of Materials Science And Engineering Chongqing University
-
Li Ying
Department Of Biochemistry And Molecular Biology Nihon University School Of Dentistry At Matsudo
-
Lou Hongxiang
Department Of Pharmacy Shandong Medical University
-
Chang Wenqiang
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University
-
Cheng Aixia
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University
-
Li Ying
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University
-
Lou Hongxiang
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University
-
Liu Yongqing
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University
-
Zhang Li
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University
関連論文
- In Vitro Evaluation of Topical Microemulsion of Capsaicin Free of Surfactant(Miscellaneous)
- Multiwavelength Photon Spectra from Microquasars
- A Nitroimidazole Derivative, PR-350, Enhances the Killing of Pancreatic Cancer Cells Exposed to High-dose Irradiation under Hypoxia
- G11R mutation in GJB6 gene causes hidrotic ectodermal dysplasia involving only hair and nails in a Chinese family
- Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway
- Optical CCD Photometry of the Variability of the BL Lacertae Object ON 231 in a Low State
- Cardiac Functional Analysis by Electrocardiography, Echocardiography and in situ Hemodynamics in Streptozotocin-Induced Diabetic Mice
- Cyclic Codes over F_p+uF_p+…+u^F_p(Coding Theory)
- A Low Cost Correlator Structure in the Pseudo-Noise Code Acquisition System
- Agonistic and Antagonistic Effects of C5a-Chimera Bearing S19 Ribosomal Protein Tail Portion on the C5a Receptor of Monocytes and Neutrophils, Respectively
- Bacterial Population in Russian Space Station "Mir"
- Fragile structured layers on surfaces detected by dynamic atomic force microscopy in aqueous electrolyte solutions
- Interaction forces between hydrophilic surfaces in electrolyte dimethyl sulfoxide solutions measured by atomic force microscopy
- Photocatalytic Decomposition of Environmentally Persistent Perfluorooctanoic Acid
- Natural Variances in Blood Pressure Category among Chinese Adults
- Trends in Prevalence, Awareness, Treatment and Control of Hypertension in the Middle-Aged Population of China, 1992-1998
- Development of Fluoride-free Mold Powders for Peritectic Steel Slab Casting
- Copper-Induced Proline Synthesis is Associated with Nitric Oxide Generation in Chlamydomonas reinhardtii
- Reduction of Early Growth Response-1 Gene Expression in Osteoblasts by Hydrogen Peroxide
- Hypoglycemic Effects and Mechanisms of Action of Cortex Lycii Radicis on Alloxan-Induced Diabetic Mice
- Structural Optimization Considering Flexibility : Structural Design of Actuators Using Piezoceramics
- Protective effects of BML-111, a lipoxin A_4 receptor agonist, on carbon tetrachloride-induced liver injury in mice
- The Effect of Calcium Hydroxide Removal and the Influence on the Sealing Ability of Root Canals
- The Involvement of Calcium Mobilization in the Calcium Activated Potassium Currents Activated by Hyposmotic Swelling in Gastric Antral Circular Myocytes of the Guinea-Pig
- Free fatty acid metabolic profile and biomarkers of isolated post-challenge diabetes and type 2 diabetes mellitus based on GC-MS and multivariate statistical analysis
- Multicolor Photometry of the Galaxies in Abell 1775 : Substructures, Luminosity Functions, and Star-Formation Properties
- Gamma-Ray-Bright Blazars : The Spectral Properties in X-Rays and Gamma-Rays
- Studies on the α-β Transition of Quartz by Means of in situ X-Ray Topography
- Observation of Satellite Reflections in the Intermediate Phase of Quartz
- The Multiwavelength Doppler Factors for a Sample of Gamma-Ray Loud Blazars
- Hydrogen Peroxide Reduced Osteomodulin Gene Expression in MC3T3-E1
- Multi-Wavelength Variation Properities of γ-Ray-Loud Blazars
- Protective effects of trichostatin A on liver injury in septic mice
- Tannins and Flavonol Glycosides from the Leaves of Euphorbia pekinensis(Natural Medicine Note)
- Effect of arsenic trioxide on the treatment of children with newly diagnosed acute promyelocytic leukemia in China
- Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work
- Non-rigid Object Tracking as Salient Region Segmentation and Association
- X-Ray and Gamma-Ray Emission of the Shell-Type Supernova Remnant RX J1713.7-3946
- Retigeric Acid B Enhances the Efficacy of Azoles Combating the Virulence and Biofilm Formation of Candida albicans
- BMI is Strongly Associated With Hypertension, and Waist Circumference is Strongly Associated With Type 2 Diabetes and Dyslipidemia, in Northern Chinese Adults
- Effect of the Decompressive Extent on the Magnitude of the Spinal Cord Shift after Expansive Open-door Laminoplasty
- Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas
- Estimates of Emission-Region Locations of Fermi Flat-Spectrum Radio Quasars
- Doxorubicin-Loaded Zein in Situ Gel for Interstitial Chemotherapy
- Clinical diagnosis and treatment of acute fatty liver of pregnancy : A literature review and 11 new cases
- A Fast and Accurate Two-Stage Algorithm for 1-bit Compressive Sensing
- The Preparation of Nickel Hydroxide Based on Infinite Dilute Method and Its Electrochemical Performance
- Determination of Selected Nitropolycyclic Aromatic Hydrocarbons in Water Samples
- The Preparation of Nickel Hydroxide Based on Infinite Dilute Method and Its Electrochemical Performance
- Mean platelet volume is negatively associated with bone mineral density in postmenopausal women
- A simple, rapid, economical, and practical method for the determination of efavirenz in plasma of Chinese AIDS patients by reverse phase high-performance liquid chromatography with ultraviolet detector