Cardiac Functional Analysis by Electrocardiography, Echocardiography and in situ Hemodynamics in Streptozotocin-Induced Diabetic Mice
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概要
- 論文の詳細を見る
Diabetic animal models are used extensively to dissect the mechanisms underlying diabetic cardiomyopathy. For such studies, detection of cardiac dysfunction is critical, and therefore, the present study comparatively examined cardiac function in mice 100 days after strepotozotocin (STZ)-induced diabetes using three complementary techniques : electrocardiography (ECG), echocardiography and left ventricular (LV) hemodynamic analysis. Histological changes were also assessed by periodic acid-Schiff (PAS)-positive materials and Masson's trichrome staining and immunohistochemical staining for type IV collagen. ECG monitoring for 2 hr in diabetic and control mice revealed no abnormality. By echocardiography, diabetic mice showed significant decreases in LV chamber diameter at end-diastole and end-systole but no other abnormalities, as compared to control mice. Hemodynamic evaluation in diabetic mice revealed that although basal parameters of cardiac function were similar to control, β-adrenergic responsiveness was significantly reduced in diabetic mice, indicating a loss of inotropic reserve and early myocardial dysfunction. Histological staining showed mild but significant increases in interstitial fibrosis in diabetic mice, confirming early diabetic cardiomyopathy. These results indicate that despite examination by ECG and resting hemodynamic may not sensitive approaches to reveal early diabetic cardiomyopathy, resting echocardiography and stressing hemodynamic analysis by evaluation of contractile provocation and inotropic reserve are able to uncover the evidence of early subtle mechanical dysfunction.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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ZHANG Li
Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force
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Cai Lu
The Chinese-american Res. Inst. For Diabetic Complications
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Cai Lu
Departments Of Hematology And Oncology At The First Clinical College:mh Radiobiology Research Unit A
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Cai Lu
Department Of Medicine University Of Louisville:pharmacology And Toxicology University Of Louisville
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Li Yan
Department Of Dermatology Affiliated Union Hospital Tongji Medical College Huazhong University Of Sc
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Cai Lu
米国
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Li Yan
Department Of Applied Physics Graduate School Of Engineering Osaka University
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Kang Y.
Department Of Medicine University Of Louisville:pharmacology And Toxicology University Of Louisville
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Gu Yan
Department of Medicine, University of Louisville
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Song Ye
Department of Medicine, University of Louisville
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Prabhu Sumanth
Department of Medicine, University of Louisville
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Li Y
Graduate School Of Engineering Tottori University
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Gu Yan
Department Of Medicine University Of Louisville:physiology And Biophysics University Of Louisville
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Song Ye
Department Of Medicine University Of Louisville
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Prabhu Sumanth
Department Of Medicine University Of Louisville:physiology And Biophysics University Of Louisville:l
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Zhang Li
Department Of Biochemistry And Molecular Biology College Of Life Science Nanjing Agricultural Univer
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Zhang Li
Department Of Medicine University Of Louisville
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Li Yan
Department Of Medicine University Of Louisville
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Li Yan
Department Of Applied Chemistry Graduate School Of Engineering Kyushu University
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KANG Y.
Department of Chemical Engineering, Konkuk University
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