Effect of Molecular Mass on Antitumor Activity of Heteropolysaccharide from Poria cocos
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概要
- 論文の詳細を見る
A water-soluble heteropolysaccharide ac-PCM0 from Poria cocos was successfully fractionated using a preparative size exclusion chromatography (SEC) column, and their weight-average molecular mass (Mw) was characterized by analytical SEC combined with laser light scattering (SEC-LLS). The results indicate that the fractions having relatively high Mw exhibited higher inhibition ratio in vivo antitumor activity than those having Mw below 3.29×104. However, the relatively low molecular mass was beneficial to the in vitro antitumor activity. Moreover, ac-PCM0 has a significantly higher enhancement ratio of the body weight than 5-fluorouracil, and its 50% lethal dose is above 1250 mg/kg, indicating a nontoxic nature.
- 社団法人 日本農芸化学会の論文
- 2005-03-23
著者
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Zhang Lina
Department Of Chemistry Wuhan University
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Zhang L
Wuhan Univ. Wuhan Chn
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Zhang Lide
Department Of Physiology China Medical University Shenyang P. R. Of China
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ZENG Fanbo
Pharmacy College, Tongji Medical University
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Chen Li
Department Of Electrical And Electronic Engineering Akita University
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Zeng Fanbo
Tongji Medical College Huazhong University Of Science And Technology
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Zhang Lina
Department Of Biochemistry And Molecular Biology Tianjin Medical University Cancer Institute And Hos
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Xu Xiaojuan
Department Of Chemistry Wuhan University
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Cheung Peter
Department Of Biology Chinese University Of Hong Kong
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Chen Li
Department Of Chemistry Wuhan University
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Chen Li
Department Of Chemistry Pukyong National University
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