Antitumor Activities of O-Sulfonated Derivatives of (1 → 3)-α-D-Glucan from Different Lentinus edodes

スポンサーリンク

概要

• 論文の詳細を見る

• Four water-insoluble (1→3)-α-D-glucans, coded L-II1, L-II2, L-II3 and L-II4, with different molecular weights were isolated from four kinds of fruiting bodies of Lentinus Edodes. The four α-D-glucans were O-sulfonated to obtain derivatives (SL-II) having degrees of substitution (DS) from 0.9 to 2.1 respectively. The structure of the samples was analyzed by infrared spectra, elemental analysis, and 13C NMR. The weight-average molecular weight (Mw), radii of gyration (〈s2〉z1⁄2) and intrinsic viscosity ([η]) of the native α-D-glucans and O-sulfonated derivatives were measured by size-exclusion chromatography combined with laser light scattering (SEC-LLS), LLS, and viscometry in 0.2 M aqueous NaCl and in dimethyl sulfoxide (DMSO) containing 0.25 M LiCl at 25 °C respectively. The Mw values of the O-sulfonated derivatives were much lower than those of the native α-D-glucans. The experimental results indicate that the O-sulfonated derivatives are water-soluble and exist as an expanded flexible chain in aqueous solution owing to intramolecular hydrogen bonding or interaction between charge groups. The in vivo and in vitro antitumor activities of the native α-D-glucans and their O-sulfonated derivatives against solid tumor Sarcoma 180 cells were evaluated and compared. Interestingly, all of the O-sulfonated derivatives exhibited higher antitumor activities than those of the native glucans. The results reveal that the effect of O-sulfonation of the α-D-glucan on the improvement of their antitumor activities was considerable.

• 社団法人 日本農芸化学会の論文
• 2006-01-23

著者

• Zhang Lina

  Department Of Chemistry Wuhan University

• Zhang L

  Wuhan Univ. Wuhan Chn

• Zhang Lide

  Department Of Physiology China Medical University Shenyang P. R. Of China

• ZENG Fanbo

  Pharmacy College, Tongji Medical University

• Zeng Fanbo

  Tongji Medical College Huazhong University Of Science And Technology

• Zhang Lina

  Department Of Biochemistry And Molecular Biology Tianjin Medical University Cancer Institute And Hos

• Xu Xiaojuan

  Department Of Chemistry Wuhan University

• UNURSAIKHAN Surenjav

  Department of Chemistry, Wuhan University

• Unursaikhan Surenjav

  Department Of Chemistry Wuhan University

関連論文

• PJ-573 Dantrolene Prevents Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) by Correcting Abnormal Ca^ Release through the Ryanodine Receptor(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annu
• FRS-018 Marked Increase in Spontaneous Ca2+ Sparks In Response To β-stimulation As A Critical Cause Of Catecholaminergic Polymorphic Ventricular Tachycardia(New Insights into Basic Mechanism of Arrhythmia(A),Featured Research Session,The 72nd Annual Scien
• PE-164 Defective Inter-domain Interaction may Cause Spontaneous Ca^ Release via Reduced Affinity of Calmodulin Binding to RyR2 in Failing Hearts(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
• Morphology and Amorphous Structure of Blend Membranes from Cellulose and Casein Recovered from Its Cuprammonium Solution
• Transition from Triple Helix to Coil of Lentinan in Solution Measured by SEC, Viscometry, and ^C NMR
• Triple Helix of β-D-Glucan from Lentinus Edodes in 0.5 M NaCl Aqueous Solution Characterized by Light Scattering
• Solution Properties of Antitumor Sulfated Derivative of α-(1→3)-D-Glucan from Ganoderma lucidum
• Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies
• A Convennient Synthetic Route to Gold Nanoparticles Dispersed within Mesoporous Silica
• Purification and Characterization of Two Novel and Kidney-Specific Proteins Related to Aminoacylase-1 and Lambda-Crystallin
• Chemical Structure and Molecular Weights of α-(1→3)-D-Glucan from Lentinus edodes
• A Novel Route to Prepare Nano-Hg_2Cl_2 Arrays
• Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2^ Knock-In Mouse Model
• Solubility of Cellulose in NaOH/Urea Aqueous Solution
• Chemical Structure of the Water-Insolube Polysaccharide Isolated from the Fruiting Body of Ganoderma lucidum
• Assessment of VEGF-D expression measured by immunohistochemical staining and F-18 FDG uptake on PET as biological prognostic factors for recurrence in patients with surgically resected lung adenocarcinoma
• Effect of Molecular Mass on Antitumor Activity of Heteropolysaccharide from Poria cocos
• Antitumor Activities of O-Sulfonated Derivatives of (1 → 3)-α-D-Glucan from Different Lentinus edodes
• A Simple Method for Synthesizing Copper Nanotube Arrays
• Novel Synthesis of Tin Dioxide Nanoribbons via a Mild Solution Approach
• Fabrication of MgO Hierarchical Nanostructures by a Thermal Evaporation Method
• VEGF-A and its isoform VEGF_ mRNA expression measured by quantitative real-time RT-PCR : correlation with F-18 FDG uptake and aggressiveness of lung adenocarcinoma : preliminary study
• Aggregation of Aeromonas Gum in Aqueous Solution
• mTOR and PTEN expression in non-small cell lung cancer : analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry

もっと見る 閉じる

スポンサーリンク