Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome
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概要
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Background: The study was carried out to examine the effect of selective α1 adrenoceptor agonist midodrine hydrochloride vs. β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS). Methods and Results: Fifty-three children with POTS were divided into group I (midodrine hydrochloride plus conventional therapy), group II (metoprolol plus conventional therapy) and group III (conventional therapy). Standing test was conducted for all participants. The cure rate, improvement rate, effective rate and score of symptoms were compared among the 3 groups. A Kaplan-Meier survivorship curve was used to describe the proportion of symptom-free cases during a long term follow-up. The cure rate and effective rate at the end of short term follow-up in group I were significantly higher than those of group II and group III (68.42% vs. 42.11% vs. 20.00%, P<0.05; 89.47% vs. 57.89% vs. 53.33%, P<0.05). After treatment, the symptom score in group I was significantly lower than group II and group III, respectively (1.1±2.2 vs. 2.8±2.4 vs. 3.7±2.0, P<0.05), and it also had significant difference between group II and group III (P<0.05). The symptom recurrent rate in group I was significantly lower than that of group II and group III, respectively (P<0.05), but it did not differ between group II and group III (P>0.05). Conclusions: Midodrine hydrochloride is effective in the treatment of children with POTS. (Circ J 2011; 75: 927-931)
- 2011-03-25
著者
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Tang Chaoshu
Institute of Cardiovascular Research, Peking University First Hospital
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Du Junbao
Departments Of Pediatrics:key Laboratory Of Molecular Cardiovascular Sciences Ministry Of Education
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Du Junbao
Department Of Pediatrics Peking University First Hospital
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Tang Chaoshu
Institute Of Cardiovascular Research First Hospital Peking University:key Laboratory Of Molecular Ca
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Jin Hongfang
Department Of Pediatrics Peking University First Hospital And Key Laboratory Of Molecular Cardiovasc
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陳 莉
広島県立大院生物生産システム研究科
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Qin Jiong
Department Of Pediatrics Peking University First Hospital
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Chen Li
Department Of Electrical And Electronic Engineering Akita University
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Jin Hongfang
Department Of Pediatrics Peking University First Hospital
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Chen Li
Department Of Gastroenterology Union Hospital Of Fujian Medical University
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WANG Li
Health Science Center, Peking University
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SUN Jinghui
Department of Pediatrics, Jilin University First Hospital
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TANG Chaoshu
Health Science Center, Peking University
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Tang Chaoshu
Health Science Center Peking University
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Wang Li
Health Science Center Peking University
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Chen Li
Department Of Chemistry Pukyong National University
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Sun Jinghui
Department Of Pediatrics Jilin University First Hospital
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