Down-Regulation of Endogenous Hydrogen Sulfide Pathway in Pulmonary Hypertension and Pulmonary Vascular Structural Remodeling Induced by High Pulmonary Blood Flow in Rats
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概要
- 論文の詳細を見る
Background The mechanisms responsible for the development of pulmonary hypertension (PH) and pulmonary vascular structural remodeling induced by high pulmonary blood flow are not fully understood. The present study was designed to explore the possible changes in endogenous hydrogen sulfide (H_2S), a novel gasotransmitter, on the pathogenesis of PH and pulmonary vascular structural remodeling induced by high pulmonary blood flow. Methods and Results Twenty-two male Sprague-Dawley rats were randomly divided into a shunting group (n=11) and control group (n=11). Rats in the shunting group underwent an abdominal aorta-inferior cava vein shunting operation. After 11 weeks of shunting, the plasma level of H_2S and lung tissue H_2S producing rate were much lower than those of the control group (p<0.01). In situ hybridization analysis showed that the expression of cystathionine γ-lyase (CSE) mRNA was down-regulated in the pulmonary arteries of the shunting rats compared with the control group (p<0.01), and competitive quantitative reverse transcription-polymerase chain reaction showed that the relative amount of CSEmRNA in lung tissue was decreased significantly (p<0.01). Conclusions The endogenous H_2S pathway is down-regulated in PH and pulmonary vascular structural remodeling is induced by high pulmonary blood flow.
- 社団法人日本循環器学会の論文
- 2005-10-20
著者
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Li Jian
Department Of Structural Engineering
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Shi Lin
Department of Chemistry, Tsinghua University
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Li Xiaohui
Department Of Pediatrics Peking University First Hospital And Key Laboratory Of Molecular Cardiovasc
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Du Junbao
Department of Pediatrics, Peking University First Hospital and Key Laboratory of Molecular Cardiovas
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Tang Xiuying
Laboratory of Electron Microscopy, Peking University First Hospital
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Qi Jianguang
Department of Pediatrics, Peking University First Hospital and Key Laboratory of Molecular Cardiovas
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Wei Bing
Department of Pediatrics, Peking University First Hospital and Key Laboratory of Molecular Cardiovas
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Jin Hongfang
Department of Pediatrics, Peking University First Hospital and Key Laboratory of Molecular Cardiovas
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Tang Chaoshu
Institute of Cardiovascular Research, Peking University First Hospital
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Wei Bing
Departments Of Pediatrics:key Laboratory Of Molecular Cardiovascular Sciences Ministry Of Education
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Du Junbao
Departments Of Pediatrics:key Laboratory Of Molecular Cardiovascular Sciences Ministry Of Education
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Du Junbao
Department Of Pediatrics Peking University First Hospital
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Qi Jianguang
Departments Of Pediatrics:key Laboratory Of Molecular Cardiovascular Sciences Ministry Of Education
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Tang Chaoshu
Institute Of Cardiovascular Research First Hospital Peking University:key Laboratory Of Molecular Ca
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Tang Xiuying
Laboratory Of Electron Microscopy Peking University First Hospital
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Jin Hongfang
Department Of Pediatrics Peking University First Hospital And Key Laboratory Of Molecular Cardiovasc
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Shi Lin
Department Of Chemistry Tsinghua University
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Li Jian
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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Li Jian
Thoracic Surgery First Hospital Peking University:key Laboratory Of Molecular Cardiovascular Science
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Jin Hongfang
Department Of Pediatrics Peking University First Hospital
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Li Xueying
Department Of Statistics Peking University First Hospital
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Qi Jianguang
Department Of Pediatrics Peking University First Hospital
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Shi Lin
Department Of Pediatrics Peking University First Hospital And Key Laboratory Of Molecular Cardiovasc
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Li Jian
Department Of Applied Mathematics Northwestern Polytechnical University
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