Antitumor Activity of the Procyanidins from Pinus koraiensis Bark on Mice Bearing U14 Cervical Cancer
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概要
- 論文の詳細を見る
Pinus koraiensis Bark Procyanidins Extract (PKBPE) has been used in traditional Chinese medicine for thousands of years. In this study, we determined PKBPE effect on tumor weight, SOD (superoxidate dismutase) activity, the content of MDA (malondialdehyde) through colorimetric analysis antigenic, and expression of Ki-67, p53 and Bcl-2 on mice bearing U14 cervical cancer. Treatment with PKBPE (158 and 250 mg/kg body weight, p.o.) could inhibit U14 cervical carcinoma growth up to 47.68 and 58.94%. In addition, PKBPE enhance the activity of SOD (p<0.01) and decrease MDA content. Furthermore, we also observed that PKBPE treatment significantly inhibited the expression of Ki-67, mutant p53 and Bcl-2 protein (p<0.01). The results suggested that PKBPE showed antitumor activities on U14 cervical carcinoma mice. The mechanism of PKBPE antitumor activity might be associated with free radical production inhibition and regulation of the expression of Ki-67, mutant p53 and Bcl-2 protein.
- 公益社団法人日本薬学会の論文
- 2007-07-01
著者
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Li Jian
Department Of Structural Engineering
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Li Kun
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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Li Kun
Department Of Applied Physics And Materials Research Center The Hong Kong Polytechnic University
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Gao DaWei
Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan Univers
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LI Qingwang
Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan Univers
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Zhang Tao
College Of Basic Medicine Jiamusi University
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Li Jian
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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Gao Dawei
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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Li Qingwang
中華人民共和国
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Li Qingwang
College Of Animal Science And Technology Northwest A&f University:department Of Biological Engin
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Han Zhengsheng
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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ZHENG Fulu
Renmin Hospital of Qinhuangdao
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Li Jian
Department Of Applied Mathematics Northwestern Polytechnical University
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