Influence of Glycemic Variability on the HbA1c Level in Elderly Male Patients with Type 2 Diabetes
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概要
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Objective To investigate the influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes (T2DM). Methods The 24-h glucose profiles were obtained using a continuous glucose monitoring system in 291 elderly male type 2 diabetic patients. The relationship between the glycemic variability and HbA1c level was assessed in these patients. Results The mean amplitude of glycemic excursions (MAGE) in patients with HbA1c ≥7.0% was significantly higher than in patients with HbA1c <7.0% (4.33±1.67 vs. 3.48±1.46 mmol/L, p<0.001). A simple (Pearson's) correlation analysis indicated that the MAGE was significantly correlated with the HbA1c (r=0.229, p<0.001). Compared with the lowest quartile, the highest quartile of the MAGE was associated with a significantly increased risk of having a HbA1c ≥7.0% after multiple adjustments (p for trend <0.001). Conclusion The glycemic variability had a significant influence on the HbA1c level in elderly male patients with T2DM. The present data suggests that patients with higher glycemic variability might have higher HbA1c levels.
著者
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Li Chun-lin
Department And Graduate Institute Of Entomology National Taiwan University
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Tian Hui
Department Of Radiology Oita University Faculty Of Medicine
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Li Jian
Department Of Applied Mathematics Northwestern Polytechnical University
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Li Jian
Department of Geriatric Endocrinology, Chinese PLA General Hospital, China
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Fang Fu-Sheng
Department of Geriatric Endocrinology, Chinese PLA General Hospital, China
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Li Zhi-Bing
Department of Geriatric Endocrinology, Chinese PLA General Hospital, China
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Cheng Xiao-Ling
Department of Geriatric Endocrinology, Chinese PLA General Hospital, China
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Tian Hui
Department of Geriatric Endocrinology, Chinese PLA General Hospital, China
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