Effect of Lycium barbarum Polysaccharide on the Improvement of Insulin Resistance in NIDDM Rats
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概要
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Lycium barbarum is one of the traditional oriental medicines. It has been reported to reduce blood glucose levels. In this study, the effect of Lycium barbarum polysaccharide (LBP) on the improvement of insulin resistance and lipid profile was studied in rats, a model for non-insulin dependent diabetes mellitus (NIDDM). The rats were divided into three groups : control, NIDDM control, and NIDDM+LBP. Diabetes model groups were made by feeding high-fat diet and subjecting to i.p. streptozotocin (50mg/kg). LBP treatment for 3 weeks resulted in a significant decrease in the concentration of plasma triglyceride and weight in NIDDM rats. Furthermore, LBP markedly decreased the plasma cholesterol levels and fasting plasma insulin levels, and the postprandial glucose level at 30min during oral glucose tolerance test and significantly increased the Insulin Sensitive Index in NIDDM rats. In the present study, we have tested that LBP can alleviate insulin resistance and the effect of LBP is associated with increasing cell-surface level of glucose transporter 4 (GLUT4) in skeletal muscle of NIDDM rats. Under insulin stimulus, GLUT4 content in plasma membrane in NIDDM control rats was significantly lower than that of control (p<0.01), and GLUT4 content in the plasma membrane in NIDDM+LBP rats was higher than that of NIDDM control rats (p<0.01). In conclusion, LBP can ameliorate insulin resistance, and the mechanism may be involved in increasing cell-surface level of GLUT4, improving GLUT4 trafficking and intracellular insulin signaling.
- 社団法人日本薬学会の論文
- 2005-12-01
著者
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Xiao Bo
College Of Animal Science And Technology Northwest A&f University:college Of Life Sciences Ludon
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Zhao Rui
Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan Univers
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LI Qingwang
Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan Univers
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XIAO Bo
School of Animal Science, Northwest A&F University
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Zhao Rui
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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Li Qingwang
中華人民共和国
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Li Qingwang
College Of Animal Science And Technology Northwest A&f University:department Of Biological Engin
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Zhao Rui
Department Of Biological Engineering College Of Environment & Chemical Engineering Yanshan Unive
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