Meta-Analysis of Randomized Controlled Trials on Treatment of Pulmonary Arterial Hypertension

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概要

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• biBackground:/i/b The aim of the present meta-analysis was to evaluate the efficacy and safety of treating pulmonary arterial hypertension (PAH) with inhaled iloprost, oral bosentan and sildenafil. biMethods and Results:/i/b The randomized controlled trials on the 3 drugs and placebo were retrieved from the databases MEDLINE, EMBASE, BIOSIS Previews and CNKI up to August 2009. In total 11 studies and 1,391 patients were selected. Compared with placebo, iloprost, bosentan and sildenafil reduced clinical worsening significantly (odds ratio [OR] =0.33, 95% confidence interval [CI] =0.22-0.49, P0.00001), improved New York Heart Association/World Health Organization functional class (OR =2.81, 95%CI =1.95-4.03, P0.00001), increased the 6-min walk test by 33.19 m, reduced systolic pulmonary arterial pressure, mean pulmonary arterial pressure and pulmonary vascular resistance, increased the cardiac index by 0.40 L · minsup-1/sup · msup-2/sup and increased the cardiac output by 0.53 L/min. The incidence of serious adverse events was similar in the medication groups and the placebo group (OR =1.09, 95%CI =0.69-1.71, P=0.72). In terms of the clinical worsening and functional class amelioration, insignificant differences were found among iloprost, bosentan and sildenafil, but iloprost had the highest incidence of serious adverse events among the 3 drugs. biConclusions:/i/b Inhaled iloprost and oral bosentan and sildenafil are effective and safe in treating PAH.  (iCirc J/i 2010; b74:/b 74: 1458 - 1464)br

• 社団法人　日本循環器学会の論文
• 2010-06-25

著者

• Li Xiaohui

  Department Of Pediatrics Peking University First Hospital And Key Laboratory Of Molecular Cardiovasc

• Tang Chaoshu

  Institute of Cardiovascular Research, Peking University First Hospital

• Du Junbao

  Department Of Pediatrics Peking University First Hospital

• Tang Chaoshu

  Institute Of Cardiovascular Research First Hospital Peking University:key Laboratory Of Molecular Ca

• Tang Chaoshu

  Department Of Physiology And Pathology Peking University Health Science Center

• Jin Hongfang

  Department Of Pediatrics Peking University First Hospital

• ZHANG Fengwen

  Department of Pediatrics, Peking University First Hospital

• Li Xueying

  Department Of Statistics Peking University First Hospital

• Zhang Fengwen

  Department Of Pediatrics Peking University First Hospital

• HE Bing

  Department of Pediatrics, Renmin Hospital of Wuhan University

• LIN Guosheng

  Department of Cardiology, Renmin Hospital of Wuhan University

• Lin Guosheng

  Department Of Cardiology Renmin Hospital Of Wuhan University

• He Bing

  Department Of Pediatrics Renmin Hospital Of Wuhan University

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