Basic Studies on 5-(7-Hydroxy-3-O-phosphonocholyl)aminosalicylic Acid for the Evaluation of Microbial Overgrowth
スポンサーリンク
概要
- 論文の詳細を見る
A newly synthesized conjugate of 7-hydroxy-3-O-phosphonocholic acid (ursodeoxycholic acid monophosphate) with 5-aminosalicylic acid (5-ASA-UDCA monophosphate) was investigated to determine its suitability for the evaluation of enteric bacteria. This compound, 5-ASA-UDCA monophosphate, was efficiently deconjugated by cholylglycine hydrolase to release 5-ASA, whereas it was completely resistant to deconjugation by pancreatic and intestinal mucosal enzymes. In everted gut sac experiments, 5-ASA-UDCA monophosphate was not actively absorbed from any part of the small intestine. In animal experiments, urinary excretions of N-acetyl-5-ASA (Ac-5ASA) were measured for 24h following the oral administration of 20 mg of 5-ASA-UDCA monophosphate. Control rats excreted 276.3±89.0 μg (mean±S.E.) of Ac-5ASA, whereas the rats with intestinal bacterial overgrowth excreted more (1224.1±231.5 μg; p<0.01). These basic studies indicate that this compound is likely to offer a simple method for the evaluation of microbial overgrowth without the use of radioisotopes or expensive, special apparatus.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
-
Konishi Toshio
Department Of Hospital Pharmacy Chugoku Rosai Hospital
-
Konishi Toshio
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
-
Matsuo T
Semiconductor Leading Edge Technologies Inc
-
Takahashi M
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
-
OHTA Shunsaku
Kyoto Pharmaceutical University
-
TAKAHASHI Makoto
Surgery, Chugoku Rosai Hospital
関連論文
- Application of Zirconium Silicon Oxide Films to an Attenuated Phase-Shifting Mask in ArF Lithography
- Stabilization of ZrSi_xO_y Films by Irradiation with an ArF Excimer Laser
- Fabrication of 0.1 μm Patterns Using an Alternating Phase Shift Mask in ArF Excimer Laser Lithography
- Fabrication of 0.13-μm Device Patterns by Argon Fluoride Excimer Laser Lithography with Practical Resolution Enhancement Techniques
- Dissolution Rate Analysis of ArF Resists Based on the Percolation Model
- Study of the Bottom Antireflective Coating Process Using a High-Transparency Resist for ArF Excimer Laser Lithography
- Challenges to 0.1 μm Resolution Capability in ArF Single Layer Resist Process with Weak Resolution Enhancement Techniques
- Characterization of Chemically Amplified Resists with"Acid Amplifier"for 193nm Lithography
- Alkylation and Acylation of the 1,2,3-Triazole Ring
- Influence of Iron on the Excretion of 5-Aminolevulinic Acid by a Photohynthetic Bacterium, Rhodobacter sphaerodies
- Reductive Dimerization of Alkylidenemalonates Using Samarium(II) Diiodide and ^1H-NMR Behavior of the Dimers, 2,3-Diaryl-1,1,4,4-butanetetracarboxylates
- Reductive Dimerization of 2-Substituted Cyclopropane-1,1-dicarboxylates Using Samarium(II) Diiodide
- Total Synthesis of Kealiiquinone, an Imidazole Marine Alkaloid
- Total Synthesis of Nortopsentins A-D, Marine Alkaloids
- A New Synthetic Route toβ-Hydroxythioethers from Carbonyl Compounds Using Samarium(II) Diiodide (SmI_2)
- A Neuromagnetic Study of the Motor and Sensory Areas of the Oral Mucosa and Organs(Abstracts of Workshop in the ORAL HEALTH SCIENCE CENTER)
- Inhibition of Theophylline Metabolism by Aciclovir
- Studies on Hypolipidemic Agents. IV. : Syntheses and Biological Activities of trans- and cis-2-(4-Alkylcyclohexyl)-2-oxoethyl Arenesulfonates(Medeicinal Chemistry,Chemical)
- Increased Band 3 Protein Aggregation and Anti-band 3 Binding of Erythrocyte Membranes on Treatment with Sesamol
- Basic Studies on 5-(7-Hydroxy-3-O-phosphonocholyl)aminosalicylic Acid for the Evaluation of Microbial Overgrowth
- Neuromagnetic Analysis of Hand Precision Movement Using Magnetoencephalography (MEG)(Abstracts of Workshop in the ORAL HEALTH SCIENCE CENTER)
- Synthesis of (.+-.)-8-Deisopropyladunctin B
- Preparation of Benzo[b]furans Having Five-Membered Heterocycles at the 2-Position and 2-(4-Alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans, and Their Cysteinyl Leukotriene Receptor (cysLT1, cysLT2) Inhibitory Activity