Studies on Hypolipidemic Agents. IV. : Syntheses and Biological Activities of trans- and cis-2-(4-Alkylcyclohexyl)-2-oxoethyl Arenesulfonates(Medeicinal Chemistry,Chemical)

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概要

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• trans- and cis-2-Diazo-1-(4-alkylcyclohexyl)-1-ethanones were reacted with arenesulfonic acids to afford the corresponding 2-(4-alkylcyclohexyl)-2-oxoethyl arenesulfonates. The esteraseinhibitory activity and hypolipidemic effect of the arenesulfonates were examined, and it was found that in most cases, the trans-isomers were more active than the corresponding cis-isomers. Stereoselective syntheses of several biologically potent trans-isomers (trans-3) were also developed.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• OGAWA Kazuo

  Research Laboratories, Ikeda Mohando Co., Ltd.

• OHTA Shunsaku

  Kyoto Pharmaceutical University

• Okamoto M

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Ohta S

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Terada T

  Osaka Univ. Osaka Jpn

• TERADA TADAFUMI

  Research Institute, Taiho Pharmaceutical Co., Ltd.

• MURANAKA YOSHIYUKI

  Research Institute, Taiho Pharmaceutical Co., Ltd.

• HAMAKAWA TOSHIHIRO

  Research Institute, Taiho Pharmaceutical Co., Ltd.

• OKAMOTO MASAO

  Kyoto Pharmaceutical University

• FUJII SETSURO

  Osaka University

• Fujii S

  Osaka University

• Muranaka Yoshiyuki

  Research Institute Taiho Pharmaceutical Co. Ltd.

• Hamakawa T

  Taiho Pharmaceutical Co. Ltd. Tokushima Jpn

• Okamoto Masao

  Kyoto College Of Pharmacy

• Ogawa Kazuo

  Research And Development Center Maruzen Oil Co. Ltd.

• Ogawa K

  Research Institute Taiho Pharmaceutical Co. Ltd.

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