Hydrolysis and Absorption of a Conjugate of Ursodeoxycholic Acid with para-Aminobenzoic Acid
スポンサーリンク
概要
- 論文の詳細を見る
Hydrolysis of ursodeoxycholyl-p-aminobenzoic acid (PABA-UDCA), a synthetic bile acid conjugate used for the evaluation of the activity of intestinal bacterial growth, was studied with pancreatic enzymes, carboxypeptidase A, carboxypeptidase B, trypsin α-chymotrypsin, cholylglycine hydrolase, liver homogenate, small intestinal homogenates, and plasma, in comparison with the hydrolysis of glycocholic acid, ursodeoxycholyl-L-leucine (L-Leu-UDCA), and ursodeoxycholyl-L-lysine (L-Lys-UDCA). PABA-UDCA was specifically cleaved by bacterial cholylglycine hydrolase to ursodeoxycholic acid and para-aminobenzoic acid (PABA), but not by pancreatic enzymes. L-Leu-UDCA was cleaved by pancreatic enzymes, carboxypeptidase A, and cholylglycine hydrolase. L-Lys-UDCA was cleaved by pancreatic enzymes, carboxypeptidase B, and cholylglycine hydrolase. The small amount of glycocholic acid was cleaved by pancreatic enzymes and carboxypeptidase A and B, and cholylglycine hydrolase hydrolyzed glycocholic acid completely. In everted gut sac experiments, PABA-UDCA was absorbed by active transport in the rat terminal ileum, and the same rate of PABA was absorbed by passive diffusion in the four segments of the rat small intestine. These observations indicate that PABA-UDCA test can evaluate the activity of small intestinal bacterial growth.
- 公益社団法人日本薬学会の論文
著者
-
TAKAHASHI MAKOTO
Department of Food Science and Technology, Kyoto University
-
Maeda Yorinobu
Department Of Pharmacy Chugoku Rosai Hospital:department Of Surgery Chugoku Rosai Hospital
-
Maeda Yorinobu
Department Of Chugoku Rosai Hospital Pharmacy Surgery Medical Technology
-
Takahashi Makoto
Department Of Coloproctological Surgery Juntendo University Faculty Of Medicine
-
Takahashi Makoto
Department Of Applied Chemistry College Of Engineering Chubu University
関連論文
- Ammonia Assimilation by Glutamine Synthetase/Glutamate Syhthase System in Brevibacterium flavum
- The Axonal Regeneration Across a Honeycomb Collagen Sponge Applied to the Transected Spinal Cord
- Comparison between endoscopic and microscopic lumbar decompression using tubular retractor to perform minimally invasive surgery
- Study of Factors for Incisional Surgical Site Infection after Elective Surgery of the Lower Digestive Tract
- RELATION BETWEEN RESPIRATORY SUPPRESSION FROM SEDATION DURING ENDOSCOPY AND VITAL CAPACITY
- Intracranial Metastasis of Renal Cell Carcinoma : MR Imaging
- Determination of Urea in Serum Based on the Combination of an Enzymatic Reaction with Immobilized Urease and Ion Chromatographic Analysis
- Basic Studies on N"-Ursodeoxycholyldiethylenetriamine-N, N, N'-triacetic Acid for the Dissolution of Calcified Gallstones
- S-C-7. Clinical and Experimental Studies on Whiplash Injury
- Evaluation of Clinical Efficacy of Maeda's Nomogram for Vancomycin Dosage Adjustment in Adult Japanese MRSA Pneumonia Patients
- Expression of Odontoblastic-Related Genes in Human Dental Follicle Cells, Dental Pulp Stem Cells, and Oral Mucosal Cells
- ^I-iomazenil binding shows stress- and/or diazepam-induced reductions in mouse brain: Supporting data for ^I-iomazenil SPECT study of anxiety disorders
- Unusual renal involvement of polymyositis complicated with malignant hypertension
- Inhibition of Theophylline Metabolism by Aciclovir
- Angiomyolipoma of the Colon : Report of a Case
- The Rapid Evaluation of Intestinal Bacterial Growth Using a Conjugate of Ursodeoxycholic Acid with para-Aminobenzoic Acid
- The Effects of Intraoperative Glucose Infusion on Portal Blood Insulin Concentration and Hepatic Mitochondrial Redox State During Surgery : Comparison of Short-Term and Continuous Infusions
- Proliferating Activity of the Hair Follicular Melanocytes at the Early and Anagen III Stages in the Hair Growth Cycle : Detection by Immunocytochemistry for Bromodeoxyuridine Combined with DOPA Reaction Cytochemistry
- Cerebral Blood flow Changes During the Mastication
- Hyperlordosis of the Cervical Spine is a Risk Factor for Reconstruction Failure of 3-level or Greater Anterior Cervical Decompression and Anterior Plate Fixation Fusion
- A Case of Metastatic Small Intestine Tumor from Breast Cancer 19 Years after the Breast Operation
- Improvement of long-term survival of colorectal cancer in Japanese-Americans of Hawaii from 1990 to 2001
- A Case of Sigmoid Colon Cancer with Congenital Antithrombin III Deficiency
- Bromination of aromatic amines by use of benzyltrimethylammonium chlorobromate (1-)
- Hydrolysis and Absorption of a Conjugate of Ursodeoxycholic Acid with para-Aminobenzoic Acid
- Prognostic impact of platelet-derived growth factor in breast carcinoma patients with hematogenous metastasis
- Is DSM widely accepted by Japanese clinicians?
- A Histological Study of Cutaneous Thermal Wounds Using a Clostridium perfringens-Derived Wound Healing Substance with Wound Healing Stimulation Activity
- Preparation of Thin Palladium Membranes by a Novel Method Based on Photolithography and Electrolysis
- A Formal System for Specification Analysis of Concurrent Programs
- Epitaxial Growth of Er, Ti Doped LiNbO3 Films Prepared by Sol–Gel Method
- Debridement using a dermatome driven with compressed air (airdermatome)
- Treatment of microcystic lymphangioma with OK-432 after intralesional excision
- In situ FT-IR Study on the Transient States of Adsorbed Species during CO Oxidation by O_2 and NO over Pt/γ-Al_2O_3 Catalyst
- N Double Pole Solution for the Modified Korteweg-de Vries Equation by the Hirota's Method
- The Development of Rice Grains under Controlled Environment I. The Effects of Temperature, its Daily Range and Photoperiod During Ripening on Grain Development
- Ultrahigh-Purity Undoped GaAs Epitaxial Layers Prepared by Liquid Phase Epitaxy
- Growth of Cu(In,Ga)Se_2 Films Selenized Using Dimethylselenium
- Prevalence of inositol 1, 4, 5-triphosphate receptor type 1 gene deletion, the mutation for spinocerebellar ataxia type 15, in Japan screened by gene dosage
- High-Extinction Ratio and Low-Driving-Voltage Spatial Light Modulator by Use of Ultrahigh-Purity GaAs
- Middle-Term Results of a Prospective Comparative Study of Anterior Decompression With Fusion and Posterior Decompression With Laminoplasty for the Treatment of Cervical Spondylotic Myelopathy
- Preparation and Characterization of Ti-Doped LiNbO3 Films Grown by the Sol-Gel Method
- Pyrrolizidine alkaloids. The synthesis and absolute configuration of all stereoisomers of monocrotalic acid.
- Screening of Medicinal and Edible Plants in Okinawa, Japan, for Enhanced Proliferative and Collagen Synthesis Activities in NB1RGB Human Skin Fibroblast Cells
- Heterotopic gastric mucosa in the hilar bile duct mimicking hilar cholangiocarcinoma : report of a case
- Presence of Anterior Compression of the Spinal Cord After Laminoplasty Inhibits Upper Extremity Motor Recovery in Patients With Cervical Spondylotic Myelopathy