Anti-carcinogenic Activity of Taraxacum Plant. II

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概要

• 論文の詳細を見る

• Eleven triterpenoids (1-11) form the roots of Taraxacum japonicum (Compositae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter, 12-O-tetrade canoylphorbol-13-acetate (TPA), in Raji cells as a primary screening test for anti-tumor-promoters (cancer chemopreventive agents). Of these triterpenoids, traxasterol (1) and taraxerol (7) exhibited significant inhibitory effects on EBV-EA induction, but the inhibitory effects of their acetates 2 and 8 were weaker than those of and 7. Furthermore, 1 and 7 exhibited potent anti-tumor-promoting activity in the two-stage carcinogenesis tests of mouse using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter, and 1 showed a remarkable inhibitory effect on mouse spontaneous mammary tumors using C3H/OuJ mouse. These results strongly suggested that traxasterol (1) could be a valuable chemopreventive agent.

• 公益社団法人日本薬学会の論文
• 1999-06-15

著者

• 上田 博之

  昭和薬大

• Kim Tae-hoon

  Faculty Of Pharmaceutical Sciences Okayama University

• Kim Tae

  Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• MASUDA Kazuo

  Showa Pharmaceutical University

• Arai Y

  Showa Pharmaceutical University

• 荒井 洋子

  富士レビオ(株)医薬研究所

• Arai Yoko

  Showa College Of Pharmaceutical Sciences

• Masuda K

  Showa Pharmaceutical Univ.

• Masuda Kazuo

  Showa College Of Pharmaceutical Sciences

• SHIOJIMA Kenji

  Showa Pharmaceutical University

• AGETA Hiroyuki

  Showa Pharmaceutical University

• Konishi Toshio

  Pharmacy:chugoku Rosai Hospital

• Masuda K

  Showa Pharmaceutical University

• KONOSHIMA Takao

  Kyoto Pharmaceutical University

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• TAKASAKI Midori

  Kyoto Pharmaceutical University

• Konoshima T

  Kyoto Pharmaceutical University

• 塩島 憲治

  Showa Pharmaceutical University

• Masuda K

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• Konishi T

  Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn

• Shiojima Kenji

  Ntt Photonics Laboratories

• Shiojima Kenji

  Showa College Of Pharmaceutical Sciences

• Ageta Hiroyuki

  Showa College Of Pharmaceutical Sciences

• 上田 博之

  Showa Coll. Pharmaceutical Sci. Tokyo Jpn

• 米谷 民雄

  Division Of Foods National Institute Of Health Sciences

• TOKUDA Karukuni

  Kyoto Prefectural University of Medicine

• Konoshima T

  Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Konoshima T

  Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Konoshima Takao

  Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

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