Anti-tumor-Promoting Activities of Triterpenoids from Ferns. I
スポンサーリンク
概要
- 論文の詳細を見る
To search for possible anti-tumor-promoters (cancer chemopreventive agents), we carried out primary screening of 23 triterpenoid hydrocarbons (1-23) isolated from ferns using an in vitro synergistic assay system. Of these triterpenoids, hop-17(21)-ene (2), neohop-13(18)-eme (3), neohop-12-ene (4), teraxerane (17), multiflor-9(11)-ene(18), multiflor-8-ene (19), glutin-5(10)-ene (21) and taraxastane (23) exhibited remarkable inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Further, compounds 2 and 3 exhibited remarkable anti-tumorpromoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethybenz[α]anthracene (DMBA) as an initiator and TPA as a promoter.
- 公益社団法人日本薬学会の論文
- 1996-07-15
著者
-
上田 博之
昭和薬大
-
Kim Tae-hoon
Faculty Of Pharmaceutical Sciences Okayama University
-
MASUDA Kazuo
Showa Pharmaceutical University
-
Arai Y
Showa Pharmaceutical University
-
荒井 洋子
富士レビオ(株)医薬研究所
-
Arai Yoko
Showa College Of Pharmaceutical Sciences
-
Masuda K
Showa Pharmaceutical Univ.
-
Masuda Kazuo
Showa College Of Pharmaceutical Sciences
-
SHIOJIMA Kenji
Showa Pharmaceutical University
-
AGETA Hiroyuki
Showa Pharmaceutical University
-
Masuda K
Showa Pharmaceutical University
-
KONOSHIMA Takao
Kyoto Pharmaceutical University
-
TOKUDA Harukuni
Kyoto Prefectural University of Medicine
-
TAKASAKI Midori
Kyoto Pharmaceutical University
-
Machiguchi Takahisa
Faculty Of Science Saitama University
-
Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
-
Konoshima T
Kyoto Pharmaceutical University
-
Konoshima Takao
Faculty Of Pharmacy Chiba Institute Of Science
-
塩島 憲治
Showa Pharmaceutical University
-
Masuda K
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
Shiojima Kenji
Ntt Photonics Laboratories
-
Shiojima Kenji
Showa College Of Pharmaceutical Sciences
-
Ageta Hiroyuki
Showa College Of Pharmaceutical Sciences
-
上田 博之
Showa Coll. Pharmaceutical Sci. Tokyo Jpn
-
米谷 民雄
Division Of Foods National Institute Of Health Sciences
-
Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
-
Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
-
Konoshima Takao
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
関連論文
- Cowaniin, a C-Glucosidic Ellagitannin Dimer Linked through Catechin from Cowania mexicana
- P-172 ANTIFUNGAL CONSTITUENTS FROM SANTALUM ALBUM OF INDIAN ORIGIN
- Chemical Constituents of Artemisia herba-alba Asso
- Composite Constituents : Three New Triterpene Triols Isolated from Fresh Roots of Picris hieracioides subsp. japonica
- Composite Constituents : Forty-Two Triterpenoids Including Eight Novel Compounds Isolated from Picris hieracioides subsp. japonica
- NMR Spectra of Triterpenoids. III. Oleanenes and Migrated Oleanenes
- COMPOSITE CONSTITUENT : NOVEL TRITERPENOID, IXERENOL, FROM AERIAL PARTS OF IXERIS CHINENSIS
- COMPOSITE CONSTITUENT : NOVEL TRITERPENOID, 17-EPI-LUPENYL ACETATE, FROM AERIAL PARTS OF IXERIS CHINENSIS
- NMR Spectra of Triterpenoids. II. Hopenes and Migrated Hopenes
- NMR Spectra of Triterpenoids. I. Conformation of the Side Chain of Hopane and Isohopane, and Their Derivatives
- 73(P2-3) シダ植物およびキク科植物から得られた新骨格のトリテルペノイド(ポスター発表の部)
- Studies on Inhibitors of Skins Tumor Promotion XI. : Inhibitory Effects of Flavonoids from Scutellaria baicalensis on Epstein-Barr Virus Activation and Their Anti-tumor-Promoting Activities.
- Chemical Phenotypes of the hmg1 and hmg2 Mutants of Arabidopsis Demonstrate the In-planta Role of HMG-CoA Reductase in Triterpene Biosynthesis
- Fern Constituents: Dryocrassy Formate, Sitostanyl Formate and 12α-Hydroxyfern-9(11)-ene from Cyathea podophylla
- Study on Aquatic Fern : Terpenoids of Azolla japonica
- Fern Constituents : Triterpenoids from Adiantum capillus-veneris
- Study on Constituents of Latex : Triterpenoids of Euphorbia tirucalli
- Fern Constituents : Triterpenoids Isolated from Leaflets of Cyathea lepifera
- Fern Constituents : Four New Diterpenoid Glycosides from Fresh Leaflets of Gleichenia japonica
- Fern Constituent : A New Triterpenoid Hydrocarbon, Trisnorhopane, Isolated from the Leaves of Dryopteris crassirhizoma and Gleichenia japonica
- Fern Constituents : Triterpenoids Isolated from Leaflets of Cyathea spinulosa
- Fern Constituents : Triterpenoids Isolated from the Leaves of Adiantum edgeworthii. Structures of 19α-Hydroxyadiantone and Fern-9(11)-en-25-oic Acid
- Mass Spectra of Pentacyclic Triterpenoids
- シダ植物成分 : ツルシダOleandra wallichiiのトリテルペノイド
- 21 シダ植物成分 : 数種のMicrosorium属植物から得られた新トリテルペノイド(ポスター発表の部)
- Fern Constituents : Two New Triterpenoid Hydrocarbons, Hop-16-ene and Isohop-22(29)-ene, Isolated from Davallia mariesii
- Ozone-Oxidation Products of Triterpenoid Hydrocarbons Belonging to the Hopane and Migrated Hopane Series
- SOLVENT AND LANTHANIDE SHIFTS USED TO DETERMINE THE STRUCTURE OF TWO NEW NEOHOP-18,19-EPOXIDES
- FERN CONSTITUENTS : TWO NEW MALABARICATRIENES ISOLATED FROM Lemmaphyllum microphyllum var. obovatum
- ラット酢酸胃潰瘍のIL-1βによる再発に対する新規抗潰瘍薬ラフチジンの効果
- 新規抗潰瘍薬ラフチジンのラットにおける酢酸胃潰瘍治癒および再発に対する効果
- 新規タキキニンNK-2受容体拮抗薬,TAC-363のモルモット気道収縮反応および気道過敏性に対する作用
- 新規タキキニンNK-2受容体拮抗薬TAC-363の薬理作用
- 薬学会館物語
- Fern Constituents : Triterpenoids Isolated from the Leaves of Cheiropleuria bicuspis
- Fern Constituents : Cheilanthenetriol and Cheilanthenediol. : Sesterterpenoids Isolated from the Leaves of Aleuritopteris Khunii
- FERN CONSTITUENTS : THREE FERNENOIC ACIDS AND ONE ADIANENOIC ACID ISOLATED FROM RHIZOMES OF MICROSORIUM BRACHYLEPIS AND M. NORMALE
- FERN CONSTITUENTS : CYCLOPODMENYL ACETATE, A CYCLOARTANOID HAVING A NEW 33-CARBON SKELETON, ISOLATED FROM POLYPODIUM VULGARE
- FERN CONSTITUENTS : FOUR NEW ONOCERADIENES ISOLATED FROM Lemmaphyllum microphyllum PRESL
- Acid-Induced Rearrangement of Triterpenoid Hydrocarbons Belonging to the Hopane and Migrated Hopane Series(Organic,Chemical)
- 役員等の選出制度について(日本薬学会役員選出制度の問題点)
- ERICACEOUS CONSTITUENTS : SEVENTEEN TRITERPENOIDS ISOLATED FROM THE BUDS OF RHODODENDRON MACROCEPALUM
- シダ植物のケモタキソノミ--2-ミョウギシダについて
- シダ植物のケモタキソノミ--1-アマミアオネカズラについて
- FERN CONSTITUENTS : SIX TETRACYCLIC TRITERPENOID HYDROCARBONS HAVING DIFFERENT CARBON SKELETONS, ISOLATED FROM LEMMAPHYLLUM MICROPHYLLUM VAR. OBOVATUM
- キク科植物成分 : オオジシバリおよびニガナの脂肪族およびトリテルペノイド成分
- キク科植物成分 : ヤクシソウ地上部の脂肪族およびトリテルペノイド成分
- FERN CONSTITUENTS : EUPHA-7,24-DIENE AND (20R)-DAMMARA-13 (17), 24-DIENE, TETRACYCLIC TRITERPENOID HYDROCARBONS ISOLATED FROM POLYPODIUM SPECIES
- 43 シダ植物成分 : マメヅタ属,イワヒトデ属植物に分布するonoceroidトリテルペン
- FERN CONSTITUENTS ; ONOCEROID, α-ONOCERADIENE, SERRATENE AND ONOCERANOXIDE, ISOLATED FROM LEMMAPHYLLUM MICROPHYLLUM VARIETIES
- 76 シダ植物成分:ハコネシダ葉の主トリテルペノイド,Adian-5-ene ozonideの構造決定とHopaneおよびMigrated Hopane系mono-ene等のオゾン酸化反応について
- マニラコパールの成分について
- 17 シダ植物成分 : アオネカズラおよびタイワンアオネカズラのトリテルペノイド
- 22 Migrated hopenesおよび関連トリテルペノイドの酸による転位反応と酸化成積体について
- 44 ホパン系トリテルペノイドにおける側鎖の構造について
- 41 シダ植物成分:ハコネシダのトリテルペンアルコール,Filicenol AおよびB,Tetrahymanol,ならびにIsoadiantol Bの分離と構造
- Polyphenols from the Leaves of Aronia melanocarpa
- Constituents of the Quercus suber Cork
- Anti-tumor-promoting Activity of Majonoside-R2 from Veitnamese Ginseng, Panax vietnamensis HA et GRUSHV. (I).
- Anti-tumor Promoting Activities of Isoflavonoids from Wistaria brachybotrys
- THE CONSTITUENTS OF WISTARIA BRACHYBOTRYS AND THEIR ANTI-TUMOR PROMOTING ACTIVITIES
- PC50 ANTITUMOR PROMOTER ACTIVITY OF PRINCIPLES IN ZINGIBERACEAE
- 34 シダ植物成分 : クジャクシダのトリテルペノイド,Adipedatolその他の構造
- 32.茅根のトリテルペノイドarundoin,cylindrinの構造 : 特にfernane骨核とarborane骨核の関係について
- 27. 7員環を有するトリテルペノイドSerratenediolの構造と合成
- A New Secoiridoid Glucoside, Amaronitidin, from the Peruvian Folk Medicine "Hercampuri" (Gentianella nitida)
- Anti-carcinogenic Activity of the Roots of Panax notoginseng. II
- Anti-carcinogenic Activity of Taraxacum Plant. I
- Anti-tumor-Promoting Activity of Diterpenes from Excoecaria agallocha
- Inhibitory Effects of Shouseiryu-to on Two-Stage Carcinogenesis. II.Anti-tumor-promoting Activities of Lignans from Asiasarum heterotropoides var. mandshuricum
- Anti-tumor-Promoting Activities of Triterpenoids from Ferns. I
- Biotransformation of Benzaldehyde-Type and Acetophenone-Type Derivatives by Pharbitis nil Hairy Roots
- Glucosylation of Phenolic Compounds by Pharbitis nil Hairy Roots : I. Glucosylation of Coumarin and Flavone Derivatives
- Euglobals-In-2 and-In-3,New Euglobals from Eucalyptus incrassata
- Fern Constituents : Six New Triterpenoid Alcohols from Adiantum capillus-veneris
- Fern Constituents : Adiantum cuneatum. III. Four New Triterpenoids, 4,23-Bisnor-3,4-secofilic-5(24)-en-3-al, 4,23-Bisnor-3,3-dimethoxy-3,4-secofilic-5(24)-ene, 7β, 25-Epoxyfern-9(11)-en-8α-ol and 7α, 8α-Epoxyfernan-25-ol
- Fern Constituents : Adiantum cuneatum. II. Six New Triterpenoids, Neohop-18-en-12α-ol, 13-Epineohop-18-en-12α-ol, Neohop-13(18)-en-19α-ol, Fern-7-en-25-ol, Fern-9(11)-en-25-ol, and Adian-5-en-25-ol
- Fern Constituents : Adiantum cuneatum. I. Three New Triterpenoids, Glaucanol B Acetate, 7β, 25-Epoxyfern-8-ene and 25-Norfern-7-en-10β-yl Formate
- FERN CONSTITUENTS : TWO NEW SECOFILICANE TRITERPENOIDS FROM ADIANTUM CUNEATUM
- Anti-carcinogenic Activity of Taraxacum Plant. II
- Bacopasides III-V : Three New Triterpenoid Glycosides from Bacopa monniera
- New Phenylethanoid Glycosides from Bacopa monniera
- GLYCORIC ACID POSSESSING A NEW 10-NORMEGASTIGMANE SKELETON FROM GLYCOSMIS ARBOREA
- P-445 Molecular Cloning of Squalene Cyclases from Ferns
- Inhibitory effects of terpenes on the growth of Staphylococcus aureus
- FERN CONSTITUENTS : CYCLOHOPENOL AND CYCLOHOPANEDIOL, NOVEL SKELETAL TRITERPENOIDS FROM RHIZOMES OF PYRROSIA LINGUA
- Fern Constituents : Triterpenoids Isolated from Rhizomes of Pyrrosia lingua. I
- Fern Constituents : Sesterterpenoids Isolated from Fronds of Aleuritopteris agetae
- Fern Constituents : Sesterterpenoids Isolated from Fronds of Aleuritopteris mexicana
- トリテルペノイドのX線結晶解析によるコンフォメーションの研究I
- シダ植物のケモタキソノミー(V) : 日本産Polystichum属について
- Chemical Constituents of Artemisia herba-alba Asso
- Inhibitory effects of terpenes on the growth of Staphylococcus aureus
- Polyphenols from the Leaves of Aronia melanocarpa
- Constituents of the Quercus suber Cork
- Study on Aquatic Fern : Terpenoids of Azolla japonica
- Study on Constituents of Latex : Triterpenoids of Euphorbia tirucalli(Natural Medicine Note)
- Chemotaxonomy of Ferns : Triterpenoids and rbcL gene Sequences of Polypodium, Polypodiodes and Goniophlebium
- Fern Constituents : Triterpenoids of Polypodiodes amoena
- 「子どもの育ちをとらえる視点」設定の試み : 年長児「パズル工場ゲーム」の観察記録をもとに