Anti-tumor-promoting Activity of Majonoside-R2 from Veitnamese Ginseng, Panax vietnamensis HA et GRUSHV. (I).
スポンサーリンク
概要
- 論文の詳細を見る
Seven saponins (1-7) isolated from the rhizomes and roots of Panax vietnamensis were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter, 12-O-tetrade-canoylphorbol-13-acetate (TPA), in Raji cells as a primary screening test for anit-tumor-promoters (cancer chemopreventive agents). The ocotillol-type saponin, majonoside-R2 (2), which is the major and characteristic constituent of this palnt, exhibited a significant inhibitory effect on EBV-EA activation. Furthermore, the cell cycle analysis of 2 on Raji cells was also examined and strong inhibition was observed on the effect of the cell cycle induced by TPA. Compound 2 showed potent anti-tumor-promoting activity in two-stage carcinogenesis tests of mouse skin using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA or fumonisin B1 as a promoter. Consequently, these results suggest that majonoside-R2 (2) could be a valuabel chemopreventive agent against chemical carcinogenesis.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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Kim Tae-hoon
Faculty Of Pharmaceutical Sciences Okayama University
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Duc N
Ho Chi Minh City University Of Medicine And Pharmacy
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Nishino H
Toho University School Of Pharmaceutical Sciences
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Nishino Hoyoku
Kyoto Prefectural University Of Medicine
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KONOSHIMA Takao
Kyoto Pharmaceutical University
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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TAKASAKI Midori
Kyoto Pharmaceutical University
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DUC Nguyen
Ho Chi Minh City University of Medicine and Pharmacy
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KASAI Ryoji
Ho Chi Minh City, Vietnam, and Institute of Pharmaceutical Sciences, Hiroshima University School of
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YAMASAKI Kazuo
Ho Chi Minh City, Vietnam, and Institute of Pharmaceutical Sciences, Hiroshima University School of
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Takagi Miyuki
Faculty Of Pharmacy Chiba Institute Of Science
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Yamasaki Kazuo
Ho Chi Minh City Vietnam And Institute Of Pharmaceutical Sciences Hiroshima University School Of Med
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Tokuda Harukuni
Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana
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Konoshima T
Kyoto Pharmaceutical University
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Konoshima Takao
Faculty Of Pharmacy Chiba Institute Of Science
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Kasai Ryoji
Ho Chi Minh City Vietnam And Institute Of Pharmaceutical Sciences Hiroshima University School Of Med
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima Takao
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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