Anti-tumor-Promoting Activity of the Diterpene from Excoecaria agallocha. II^<1)>
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概要
- 論文の詳細を見る
Eight new diterpenoids(1-8)have been isolated from the wood of Excoecaria agallocha(Euphorbiaceae)and their inhibitory effects on the induction of Epstein-Barr virus early antigen(EBV-EA)in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7, 12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl-phorbol-13-acetate.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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KONISHI Tenji
Kyoto Pharmaceutical University
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KONOSHIMA Takao
Kyoto Pharmaceutical University
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TOKUDA Harukuni
Kyoto Prefectural University of Medicine
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TAKASAKI Midori
Kyoto Pharmaceutical University
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Takagi Miyuki
Faculty Of Pharmacy Chiba Institute Of Science
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Tokuda H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Tokuda Harukuni
Department Of Microbiology Faculty Of Medicine Kyoto University
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Tokuda Harukuni
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Tokuda Harukuni
Dept. Of Biochemistry Kyoto Prefectural University Of Medicine
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Konoshima T
Kyoto Pharmaceutical University
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Konoshima Takao
Faculty Of Pharmacy Chiba Institute Of Science
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YAMAZOE Kiyonori
Kyoto Pharmaceutical University
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yamasaki Kazuo
Kyoto Pharmaceutical University
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Konoshima T
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Konoshima Takao
Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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